Conditions for Waveblock Due to Anisotropy in a Model of Human Ventricular Tissue

Nina Kudryashova; Ivan V Kazbanov; Alexander V Panfilov; Konstantin I Agladze

doi:10.1371/journal.pone.0141832

Conditions for Waveblock Due to Anisotropy in a Model of Human Ventricular Tissue

Nina Kudryashova, Ivan V Kazbanov, Alexander V Panfilov, Konstantin I Agladze

Research output: Contribution to journal › Article › peer-review

Abstract / Description of output

Waveblock formation is the main cause of reentry. We have performed a comprehensive numerical modeling study of block formation due to anisotropy in Ten Tusscher and Panfilov (2006) ionic model for human ventricular tissue. We have examined the border between different areas of myocardial fiber alignment and have shown that blockage can occur for a wave traveling from a transverse fiber area to a longitudinal one. Such blockage occurs for reasonable values of the anisotropy ratio (AR): from 2.4 to 6.2 with respect to propagation velocities. This critical AR decreases by the suppression of I_Na and I_Ca, slightly decreases by the suppression of I_Kr and I_Ks, and substantially increases by the suppression of I_K1. Hyperkalemia affects the block formation in a complex, biphasic way. We provide examples of reentry formation due to the studied effects and have concluded that the suppression of I_K1 should be the most effective way to prevent waveblock at the areas of abrupt change in anisotropy.

Original language	English
Pages (from-to)	e0141832
Number of pages	18
Journal	PLoS ONE
Volume	10
Issue number	11
DOIs	https://doi.org/10.1371/journal.pone.0141832
Publication status	Published - 2 Nov 2015
Externally published	Yes

Keywords / Materials (for Non-textual outputs)

Action Potentials
Anisotropy
Humans
Hyperkalemia/physiopathology
Models, Cardiovascular
Potassium Channels/metabolism
Ventricular Function

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Cite this

@article{f4a897282ba24289a5bc0d8017a09d07,

title = "Conditions for Waveblock Due to Anisotropy in a Model of Human Ventricular Tissue",

abstract = "Waveblock formation is the main cause of reentry. We have performed a comprehensive numerical modeling study of block formation due to anisotropy in Ten Tusscher and Panfilov (2006) ionic model for human ventricular tissue. We have examined the border between different areas of myocardial fiber alignment and have shown that blockage can occur for a wave traveling from a transverse fiber area to a longitudinal one. Such blockage occurs for reasonable values of the anisotropy ratio (AR): from 2.4 to 6.2 with respect to propagation velocities. This critical AR decreases by the suppression of INa and ICa, slightly decreases by the suppression of IKr and IKs, and substantially increases by the suppression of IK1. Hyperkalemia affects the block formation in a complex, biphasic way. We provide examples of reentry formation due to the studied effects and have concluded that the suppression of IK1 should be the most effective way to prevent waveblock at the areas of abrupt change in anisotropy. ",

keywords = "Action Potentials, Anisotropy, Humans, Hyperkalemia/physiopathology, Models, Cardiovascular, Potassium Channels/metabolism, Ventricular Function",

author = "Nina Kudryashova and Kazbanov, {Ivan V} and Panfilov, {Alexander V} and Agladze, {Konstantin I}",

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T1 - Conditions for Waveblock Due to Anisotropy in a Model of Human Ventricular Tissue

AU - Kudryashova, Nina

AU - Kazbanov, Ivan V

AU - Panfilov, Alexander V

AU - Agladze, Konstantin I

PY - 2015/11/2

Y1 - 2015/11/2

N2 - Waveblock formation is the main cause of reentry. We have performed a comprehensive numerical modeling study of block formation due to anisotropy in Ten Tusscher and Panfilov (2006) ionic model for human ventricular tissue. We have examined the border between different areas of myocardial fiber alignment and have shown that blockage can occur for a wave traveling from a transverse fiber area to a longitudinal one. Such blockage occurs for reasonable values of the anisotropy ratio (AR): from 2.4 to 6.2 with respect to propagation velocities. This critical AR decreases by the suppression of INa and ICa, slightly decreases by the suppression of IKr and IKs, and substantially increases by the suppression of IK1. Hyperkalemia affects the block formation in a complex, biphasic way. We provide examples of reentry formation due to the studied effects and have concluded that the suppression of IK1 should be the most effective way to prevent waveblock at the areas of abrupt change in anisotropy.

AB - Waveblock formation is the main cause of reentry. We have performed a comprehensive numerical modeling study of block formation due to anisotropy in Ten Tusscher and Panfilov (2006) ionic model for human ventricular tissue. We have examined the border between different areas of myocardial fiber alignment and have shown that blockage can occur for a wave traveling from a transverse fiber area to a longitudinal one. Such blockage occurs for reasonable values of the anisotropy ratio (AR): from 2.4 to 6.2 with respect to propagation velocities. This critical AR decreases by the suppression of INa and ICa, slightly decreases by the suppression of IKr and IKs, and substantially increases by the suppression of IK1. Hyperkalemia affects the block formation in a complex, biphasic way. We provide examples of reentry formation due to the studied effects and have concluded that the suppression of IK1 should be the most effective way to prevent waveblock at the areas of abrupt change in anisotropy.

KW - Action Potentials

KW - Anisotropy

KW - Humans

KW - Hyperkalemia/physiopathology

KW - Models, Cardiovascular

KW - Potassium Channels/metabolism

KW - Ventricular Function

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SN - 1932-6203

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SP - e0141832

JO - PLoS ONE

JF - PLoS ONE

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ER -

Conditions for Waveblock Due to Anisotropy in a Model of Human Ventricular Tissue

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Keywords / Materials (for Non-textual outputs)

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