Conditions for Waveblock Due to Anisotropy in a Model of Human Ventricular Tissue

Nina Kudryashova, Ivan V Kazbanov, Alexander V Panfilov, Konstantin I Agladze

Research output: Contribution to journalArticlepeer-review

Abstract

Waveblock formation is the main cause of reentry. We have performed a comprehensive numerical modeling study of block formation due to anisotropy in Ten Tusscher and Panfilov (2006) ionic model for human ventricular tissue. We have examined the border between different areas of myocardial fiber alignment and have shown that blockage can occur for a wave traveling from a transverse fiber area to a longitudinal one. Such blockage occurs for reasonable values of the anisotropy ratio (AR): from 2.4 to 6.2 with respect to propagation velocities. This critical AR decreases by the suppression of INa and ICa, slightly decreases by the suppression of IKr and IKs, and substantially increases by the suppression of IK1. Hyperkalemia affects the block formation in a complex, biphasic way. We provide examples of reentry formation due to the studied effects and have concluded that the suppression of IK1 should be the most effective way to prevent waveblock at the areas of abrupt change in anisotropy.

Original languageEnglish
Pages (from-to)e0141832
Number of pages18
JournalPLoS ONE
Volume10
Issue number11
DOIs
Publication statusPublished - 2 Nov 2015
Externally publishedYes

Keywords

  • Action Potentials
  • Anisotropy
  • Humans
  • Hyperkalemia/physiopathology
  • Models, Cardiovascular
  • Potassium Channels/metabolism
  • Ventricular Function

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