Conflicting candidates for cattle QTLs

Dirk-Jan de Koning

doi:10.1016/j.tig.2006.04.006

Conflicting candidates for cattle QTLs

Dirk-Jan de Koning

Royal (Dick) School of Veterinary Studies

Research output: Contribution to journal › Article › peer-review

Abstract

Genome scans have identified quantitative trait loci (QTLs) affecting milk yield and composition in dairy cattle. For one QTL on bovine chromosome 6 (BTA6), previously fine-mapped to a 420-Kb region, mutations in two different genes (OPN and ABCG2) have been proposed as the underlying functional mutation. Comparing the arguments for each gene suggests that both mutations are equally probable. However, functional studies and/or additional populations are required to provide a definite answer.

Original language	English
Pages (from-to)	301-5
Number of pages	5
Journal	Trends in Genetics
Volume	22
Issue number	6
DOIs	https://doi.org/10.1016/j.tig.2006.04.006
Publication status	Published - Jun 2006

Keywords

Animals
Cattle
Chromosome Mapping
Female
Lactation
Milk
Mutation
Quantitative Trait Loci

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10.1016/j.tig.2006.04.006

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title = "Conflicting candidates for cattle QTLs",

abstract = "Genome scans have identified quantitative trait loci (QTLs) affecting milk yield and composition in dairy cattle. For one QTL on bovine chromosome 6 (BTA6), previously fine-mapped to a 420-Kb region, mutations in two different genes (OPN and ABCG2) have been proposed as the underlying functional mutation. Comparing the arguments for each gene suggests that both mutations are equally probable. However, functional studies and/or additional populations are required to provide a definite answer.",

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AB - Genome scans have identified quantitative trait loci (QTLs) affecting milk yield and composition in dairy cattle. For one QTL on bovine chromosome 6 (BTA6), previously fine-mapped to a 420-Kb region, mutations in two different genes (OPN and ABCG2) have been proposed as the underlying functional mutation. Comparing the arguments for each gene suggests that both mutations are equally probable. However, functional studies and/or additional populations are required to provide a definite answer.

KW - Animals

KW - Cattle

KW - Chromosome Mapping

KW - Female

KW - Lactation

KW - Milk

KW - Mutation

KW - Quantitative Trait Loci

U2 - 10.1016/j.tig.2006.04.006

DO - 10.1016/j.tig.2006.04.006

M3 - Article

C2 - 16690157

VL - 22

SP - 301

EP - 305

JO - Trends in Genetics

JF - Trends in Genetics

SN - 0168-9525

IS - 6

ER -

Conflicting candidates for cattle QTLs

Abstract

Keywords

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