Conformational relaxation and ligand binding to singly reduced human embryonic haemoglobins.

Neil Robson

Research output: Contribution to journalArticlepeer-review

Abstract

The reaction of the three human embryonic haemoglobins with aquated electrons follows a complex set of steps in which a single haem centre undergoes both reduction and spin state changes coupled to slower protein relaxation events. In the presence of ferrous haem ligands the spin state changes are coupled directly to the ligand binding process. The rate constants for the reaction of the single reduced haem with O2 are similar to those determined by flash photolysis at high pH, whilst CO binding to the beta type haems is more rapid and the alpha haems less rapid than the analogous processes observed using photolysis techniques.
Original languageEnglish
Pages (from-to)1245-53
Number of pages9
JournalBiochemistry and Molecular Biology Education
Volume38
Issue number6
Publication statusPublished - 1996

Fingerprint Dive into the research topics of 'Conformational relaxation and ligand binding to singly reduced human embryonic haemoglobins.'. Together they form a unique fingerprint.

Cite this