Connecting viral with cellular interactomes

S. M. Bailer, J. Haas

Research output: Contribution to journalLiterature reviewpeer-review

Abstract

Genome-scale screens for intraviral and virus-host protein interactions and the analysis of literature-curated datasets are able to provide a novel, comprehensive perspective of viruses, and virus-infected cells. Until now, large-scale interaction screens were predominantly performed with the yeast-two-hybrid (Y2H) system; however, alternative high-throughput technologies detecting binary protein interactions or protein complexes have been developed. Although many of the previous studies suffer from a rather poor validation of the results and few biological implications, these technologies potentially lead to a plethora of novel hypotheses. Here, we will give an overview of current approaches and their technical limitations, present recent examples and novel developments.

Original languageEnglish
Pages (from-to)453-459
Number of pages7
JournalCurrent Opinion in Microbiology
Volume12
Issue number4
DOIs
Publication statusPublished - Aug 2009

Cite this