Consensus statement for diagnosis of subcortical small vessel disease

GA Rosenberg, A Wallin, Joanna Wardlaw, Hugh S Markus, J. Montaner, L Wolfson, Costantino Iadecola, BV Zlokovic, A Joutel, Martin Dichgans, Marco Duering, R Schmidt, A Koczyn , LT Grinberg, HC Chui , Vladimir Hachinski

Research output: Contribution to journalArticlepeer-review

Abstract

Vascular cognitive impairment (VCI) is the diagnostic term used to describe a heterogeneous group of sporadic and hereditary diseases of the large and small blood vessels. Subcortical small vessel disease (SVD) leads to lacunar infarcts and progressive damage to the white matter. Patients with progressive damage to the white matter, referred to as Binswanger’s disease (BD), constitute a spectrum from pure vascular disease to a mixture with neurodegenerative changes. Binswanger’s disease patients are a relatively homogeneous subgroup with hypoxic hypoperfusion, lacunar infarcts, and inflammation that act synergistically to disrupt the blood–brain barrier (BBB) and break down myelin. Identification of this subgroup can be facilitated by multimodal disease markers obtained from clinical, cerebrospinal fluid, neuropsychological, and imaging studies. This consensus statement identifies a potential set of biomarkers based on underlying pathologic changes that could facilitate diagnosis and aid patient selection for future collaborative treatment trials.
Original languageEnglish
Pages (from-to)6-25
JournalJournal of Cerebral Blood Flow and Metabolism
Volume36
Early online date22 Jul 2015
DOIs
Publication statusPublished - Jan 2016

Keywords

  • SMALL VESSEL DISEASE
  • SVD
  • subcortical

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