Context dependence of proneural bHLH proteins

Lynn M. Powell; Andrew P. Jarman

doi:10.1016/j.gde.2008.07.012

Context dependence of proneural bHLH proteins

Lynn M. Powell, Andrew P. Jarman

Deanery of Biomedical Sciences

Research output: Contribution to journal › Literature review › peer-review

Abstract

A key point in neural development is the commitment of progenitor cells to a specific neural fate. In all animals studied, proneural proteins - transcription factors of the basic helix-loop-helix (bHLH) family - are central to this process. The function of these factors is strongly influenced by the spatial and temporal context in which they are expressed. It is important to understand the molecular mechanisms by which developmental context interacts with and modifies the intrinsic functions and properties of the proneural proteins. Recent insights have been obtained in Drosophila and vertebrates from analysis of how bHLH proteins interact with other transcription factors to regulate target genes.

Original language	English
Pages (from-to)	411-417
Number of pages	7
Journal	Current Opinion in Genetics and Development
Volume	18
Issue number	5
DOIs	https://doi.org/10.1016/j.gde.2008.07.012
Publication status	Published - Oct 2008

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10.1016/j.gde.2008.07.012

Context dependence of proneural bHLH proteins
Published in final edited form as: Curr Opin Genet Dev. 2008 October ; 18(5): 411–417. doi:10.1016/j.gde.2008.07.012.
Accepted author manuscript, 305 KB

http://www.sciencedirect.com/science/article/pii/S0959437X08000919

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title = "Context dependence of proneural bHLH proteins",

abstract = "A key point in neural development is the commitment of progenitor cells to a specific neural fate. In all animals studied, proneural proteins - transcription factors of the basic helix-loop-helix (bHLH) family - are central to this process. The function of these factors is strongly influenced by the spatial and temporal context in which they are expressed. It is important to understand the molecular mechanisms by which developmental context interacts with and modifies the intrinsic functions and properties of the proneural proteins. Recent insights have been obtained in Drosophila and vertebrates from analysis of how bHLH proteins interact with other transcription factors to regulate target genes.",

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AU - Jarman, Andrew P.

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N2 - A key point in neural development is the commitment of progenitor cells to a specific neural fate. In all animals studied, proneural proteins - transcription factors of the basic helix-loop-helix (bHLH) family - are central to this process. The function of these factors is strongly influenced by the spatial and temporal context in which they are expressed. It is important to understand the molecular mechanisms by which developmental context interacts with and modifies the intrinsic functions and properties of the proneural proteins. Recent insights have been obtained in Drosophila and vertebrates from analysis of how bHLH proteins interact with other transcription factors to regulate target genes.

AB - A key point in neural development is the commitment of progenitor cells to a specific neural fate. In all animals studied, proneural proteins - transcription factors of the basic helix-loop-helix (bHLH) family - are central to this process. The function of these factors is strongly influenced by the spatial and temporal context in which they are expressed. It is important to understand the molecular mechanisms by which developmental context interacts with and modifies the intrinsic functions and properties of the proneural proteins. Recent insights have been obtained in Drosophila and vertebrates from analysis of how bHLH proteins interact with other transcription factors to regulate target genes.

U2 - 10.1016/j.gde.2008.07.012

DO - 10.1016/j.gde.2008.07.012

M3 - Literature review

SN - 0959-437X

VL - 18

SP - 411

EP - 417

JO - Current Opinion in Genetics and Development

JF - Current Opinion in Genetics and Development

IS - 5

ER -

Context dependence of proneural bHLH proteins

Abstract

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