CONTIGUOUS CLONE MAP OVER 3 MB ON THE LONG ARM OF CHROMOSOME-11 ACROSS A BALANCED TRANSLOCATION ASSOCIATED WITH SCHIZOPHRENIA

K L EVANS, J BROWN, Y SHIBASAKI, R S DEVON, L HE, B ARVEILER, S CHRISTIE, J C MAULE, D BAILLIE, E M SLORACH, S M ANDERSON, J R GOSDEN, J PETIT, A WEITH, C M GOSDEN, D H R BLACKWOOD, D M STCLAIR, W J MUIR, A J BROOKES, D J PORTEOUSSusan Anderson

Research output: Contribution to journalArticlepeer-review

Abstract

Forty-nine clones derived by microdissection of a schizophrenia-associated t(1;11)(q42.1;q14.3) breakpoint region have been assigned by somatic cell hybrid mapping to seven discrete intervals on the long arm of human chromosome 11. Eleven of the clones were shown to map to a small region immediately distal to the translocation breakpoint on 11q. A 3-Mb contiguous clone map of this region was established by isolation of corresponding YAC recombinants. The contig was oriented and shown to traverse the translocation breakpoint by FISH and microsatellite marker analysis. This contig will facilitate the isolation of candidate sequences whose expression may be affected by the translocation. (C) 1995 Academic Press, Inc.

Original languageEnglish
Pages (from-to)420-428
Number of pages9
JournalGenomics
Volume28
Issue number3
Publication statusPublished - 10 Aug 1995

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