TY - JOUR
T1 - Continuing versus Stopping Prestroke Antihypertensive Therapy in Acute Intracerebral Hemorrhage
T2 - A Subgroup Analysis of the Efficacy of Nitric Oxide in Stroke Trial
AU - Krishnan, Kailash
AU - Scutt, Polly
AU - Woodhouse, Lisa
AU - Adami, Alessandro
AU - Becker, Jennifer L.
AU - Cala, Lesley A.
AU - Casado, Ana M.
AU - Chen, Christopher
AU - Dineen, Robert A.
AU - Gommans, John
AU - Koumellis, Panos
AU - Christensen, Hanna
AU - Collins, Ronan
AU - Czlonkowska, Anna
AU - Lees, Kennedy R.
AU - Ntaios, George
AU - Ozturk, Serefnur
AU - Phillips, Stephen J.
AU - Sprigg, Nikola
AU - Szatmari, Szabolcs
AU - Wardlaw, Joanna M.
AU - Bath, Philip M.
PY - 2016/5/1
Y1 - 2016/5/1
N2 - Background and purpose More than 50% of patients with acute intracerebral hemorrhage (ICH) are taking antihypertensive drugs before ictus. Although antihypertensive therapy should be given long term for secondary prevention, whether to continue or stop such treatment during the acute phase of ICH remains unclear, a question that was addressed in the Efficacy of Nitric Oxide in Stroke (ENOS) trial. Methods ENOS was an international multicenter, prospective, randomized, blinded endpoint trial. Among 629 patients with ICH and systolic blood pressure between 140 and 220 mmHg, 246 patients who were taking antihypertensive drugs were assigned to continue (n = 119) or to stop (n = 127) taking drugs temporarily for 7 days. The primary outcome was the modified Rankin Score at 90 days. Secondary outcomes included death, length of stay in hospital, discharge destination, activities of daily living, mood, cognition, and quality of life. Results Blood pressure level (baseline 171/92 mmHg) fell in both groups but was significantly lower at 7 days in those patients assigned to continue antihypertensive drugs (difference 9.4/3.5 mmHg, P
AB - Background and purpose More than 50% of patients with acute intracerebral hemorrhage (ICH) are taking antihypertensive drugs before ictus. Although antihypertensive therapy should be given long term for secondary prevention, whether to continue or stop such treatment during the acute phase of ICH remains unclear, a question that was addressed in the Efficacy of Nitric Oxide in Stroke (ENOS) trial. Methods ENOS was an international multicenter, prospective, randomized, blinded endpoint trial. Among 629 patients with ICH and systolic blood pressure between 140 and 220 mmHg, 246 patients who were taking antihypertensive drugs were assigned to continue (n = 119) or to stop (n = 127) taking drugs temporarily for 7 days. The primary outcome was the modified Rankin Score at 90 days. Secondary outcomes included death, length of stay in hospital, discharge destination, activities of daily living, mood, cognition, and quality of life. Results Blood pressure level (baseline 171/92 mmHg) fell in both groups but was significantly lower at 7 days in those patients assigned to continue antihypertensive drugs (difference 9.4/3.5 mmHg, P
KW - Antihypertensive therapy
KW - blood pressure
KW - cerebrovascular disorders
KW - glyceryl trinitrate
KW - intracerebral hemorrhage
KW - randomized controlled trial
UR - http://www.scopus.com/inward/record.url?scp=84957092952&partnerID=8YFLogxK
U2 - 10.1016/j.jstrokecerebrovasdis.2016.01.010
DO - 10.1016/j.jstrokecerebrovasdis.2016.01.010
M3 - Article
AN - SCOPUS:84957092952
SN - 1052-3057
VL - 25
SP - 1017
EP - 1026
JO - Journal of Stroke & Cerebrovascular Diseases
JF - Journal of Stroke & Cerebrovascular Diseases
IS - 5
ER -