Contribution of CXCL12 secretion to invasion of breast cancer cells

Pamela J Boimel, Tatiana Smirnova, Zhen Ni Zhou, Jeffrey Wyckoff, Haein Park, Salvatore J Coniglio, Binzhi Qian, E Richard Stanley, Dianne Cox, Jeffrey W Pollard, William J Muller, John Condeelis, Jeffrey E Segall

Research output: Contribution to journalArticlepeer-review

Abstract

Neu (HER2/ErbB2) is overexpressed in 25% to 30% of human breast cancer, correlating with a poor prognosis. Researchers in previous studies who used the mouse mammary tumor virus Neu-transgenic mouse model (MMTV-Neu) demonstrated that the Neu-YB line had increased production of CXCL12 and increased metastasis, whereas the Neu-YD line had decreased metastasis. In this study, we examined the role of increased production of CXCL12 in tumor cell invasion and malignancy.
Original languageEnglish
Pages (from-to)R23
JournalBreast Cancer Research
Volume14
Issue number1
DOIs
Publication statusPublished - 2012

Keywords

  • Adenocarcinoma
  • Animals
  • Cell Movement
  • Chemokine CXCL12
  • Female
  • Humans
  • Lung Neoplasms
  • Macrophage Activation
  • Macrophages
  • Mammary Neoplasms, Experimental
  • Mice
  • Microscopy, Video
  • Neoplasm Invasiveness
  • Neoplasm Transplantation
  • Neoplastic Cells, Circulating
  • Paracrine Communication
  • Rats
  • Receptor, erbB-2
  • Receptors, CXCR4
  • Signal Transduction
  • Tumor Burden
  • Tumor Cells, Cultured
  • Tumor Microenvironment

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