Contribution of the NOD1/CARD4 insertion/deletion polymorphism +32656 to inflammatory bowel disease in Northern Europe

J Van Limbergen, R K Russell, E R Nimmo, L Törkvist, C W Lees, H E Drummond, L Smith, N H Anderson, P M Gillett, P McGrogan, K Hassan, L T Weaver, W M Bisset, G Mahdi, I D Arnott, U Sjöqvist, M Lördal, S M Farrington, M G Dunlop, David WilsonJ Satsangi

Research output: Contribution to journalArticlepeer-review

Abstract

NOD1/CARD4 and NOD2/CARD15 are both intracellular pattern-recognition receptors. The NOD1/CARD4 gene lies within a previously described inflammatory bowel disease (IBD) locus (7p14). An association has been suggested between the NOD1/CARD4+32656 deletion*1 variant of a complex deletion*1/insertion*2 polymorphism and IBD in 1 recent study in Europe. Our aim was to assess the influence of NOD1/CARD4+32656 on disease susceptibility and phenotype in the Scottish and Swedish IBD populations.
Original languageEnglish
Pages (from-to)882-9
Number of pages8
JournalInflammatory Bowel Diseases
Volume13
Issue number7
DOIs
Publication statusPublished - 6 Feb 2007

Keywords

  • Adolescent
  • Adult
  • Age of Onset
  • Case-Control Studies
  • Child
  • Female
  • Genetic Predisposition to Disease
  • Genotype
  • Humans
  • Inflammatory Bowel Diseases
  • Male
  • Middle Aged
  • Mutation
  • Nod1 Signaling Adaptor Protein
  • Phenotype
  • Polymorphism, Genetic
  • Scotland
  • Sweden

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