Control of innate-like B cell location for compartmentalised IgM production

Lucy H Jackson-Jones, Cécile Bénézech

Research output: Contribution to journalArticlepeer-review


Natural IgM are crucial for early protection against infection and play an important homeostatic function by clearing dead cells. The production of IgM is ensured by a population of B cells with innate-like properties: their response is rapidly activated by innate signals early during the onset of infection. The main reservoir of innate-like B cells (IBCs) are the serous cavities, but their maintenance and activation depends on their relocation to a variety of lymphoid tissues. Recent advances indicate that fat-associated lymphoid clusters (FALCs) and milky spots contribute to local IgM secretion and play a central role in the localisation and regulation of IBC function.

Original languageEnglish
Pages (from-to)9-13
Number of pages5
JournalCurrent Opinion in Immunology
Early online date5 Nov 2017
Publication statusPublished - Feb 2018


  • Journal Article
  • Review


Dive into the research topics of 'Control of innate-like B cell location for compartmentalised IgM production'. Together they form a unique fingerprint.

Cite this