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Abstract / Description of output
Signalling cascades control multiple aspects of presynaptic function. Synaptic vesicle endocytosis was assumed to be exempt from modulation, due to its essential role maintaining synaptic vesicle supply and thus neurotransmission. Here we show that brain-derived neurotrophic factor arrests the rephosphorylation of the endocytosis enzyme dynamin I via an inhibition of glycogen synthase kinase 3. This event results in a selective inhibition of activity-dependent bulk endocytosis during high-intensity firing. Furthermore, the continued presence of brain-derived neurotrophic factor alleviates the rundown of neurotransmission during high activity. Thus, synaptic strength can be modulated by extracellular signalling molecules via a direct inhibition of a synaptic vesicle endocytosis mode.
Original language | English |
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Article number | 2394 |
Journal | Nature Communications |
Volume | 4 |
DOIs | |
Publication status | Published - 3 Sept 2013 |
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Dive into the research topics of 'Control of synaptic vesicle endocytosis by an extracellular signalling molecule'. Together they form a unique fingerprint.Projects
- 1 Finished
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Abberant protein phosphorylation in down syndrome and activity-dependant bulk endocytiosis
1/01/12 → 30/06/15
Project: Research