TY - JOUR
T1 - Controlling and coordinating development in vector-transmitted parasites
AU - Matthews, Keith R
PY - 2011/3/4
Y1 - 2011/3/4
N2 - Vector-borne parasites cause major human diseases of the developing world, including malaria, human African trypanosomiasis, Chagas disease, leishmaniasis, filariasis, and schistosomiasis. Although the life cycles of these parasites were defined over 100 years ago, the strategies they use to optimize their successful transmission are only now being understood in molecular terms. Parasites are now known to monitor their environment in both their host and vector and in response to other parasites. This allows them to adapt their developmental cycles and to counteract any unfavorable conditions they encounter. Here, I review the interactions that parasites engage in with their hosts and vectors to maximize their survival and spread.
AB - Vector-borne parasites cause major human diseases of the developing world, including malaria, human African trypanosomiasis, Chagas disease, leishmaniasis, filariasis, and schistosomiasis. Although the life cycles of these parasites were defined over 100 years ago, the strategies they use to optimize their successful transmission are only now being understood in molecular terms. Parasites are now known to monitor their environment in both their host and vector and in response to other parasites. This allows them to adapt their developmental cycles and to counteract any unfavorable conditions they encounter. Here, I review the interactions that parasites engage in with their hosts and vectors to maximize their survival and spread.
UR - http://www.scopus.com/inward/record.url?scp=79952257324&partnerID=8YFLogxK
U2 - 10.1126/science.1198077
DO - 10.1126/science.1198077
M3 - Article
C2 - 21385707
VL - 331
SP - 1149
EP - 1153
JO - Science
JF - Science
SN - 0036-8075
IS - 6021
ER -