Controlling complexity: The clinical relevance of mouse complex genetics

Klaus Schughart, Claude Libert, SYSGENET, Martien Kas

Research output: Contribution to journalLiterature reviewpeer-review


Experimental animal models are essential to obtain basic knowledge of the underlying biological mechanisms in human diseases. Here, we review major contributions to biomedical research and discoveries that were obtained in the mouse model by using forward genetics approaches and that provided key insights into the biology of human diseases and paved the way for the development of novel therapeutic approaches.
Original languageEnglish
Article numberPMID: 23632795
Pages (from-to)1-6
Number of pages6
JournalEuropean Journal of Human Genetics
Early online date1 May 2013
Publication statusPublished - 1 May 2013


  • Mouse model
  • forward genetics
  • reiew


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