Conventional adjuvant chemotherapy versus single-cycle, autograft-supported, high-dose, late-intensification chemotherapy in high-risk breast cancer patients: a randomized trial

Anglo-Celtic Cooperative Oncology Group, Robert C F Leonard, Michael Lind, Christopher Twelves, Robert Coleman, Simon van Belle, Charles Wilson, Jonathan Ledermann, Ian Kennedy, Peter Barrett-Lee, Timothy Perren, Mark Verrill, David Cameron, Elizabeth Foster, Ann Yellowlees, John Crown

Research output: Contribution to journalArticlepeer-review

Abstract

Breast cancer patients with four or more positive axillary lymph nodes who are treated with conventional adjuvant therapy have a poor prognosis. In uncontrolled studies, high-dose chemotherapy produced much better results than conventional therapy. We compared the benefits of a single cycle of high-dose chemotherapy and the benefits of conventional chemotherapy in patients with high-risk breast cancer in a prospective, unblinded, randomized trial.
Original languageEnglish
Pages (from-to)1076-83
Number of pages8
JournalJNCI: Journal of the National Cancer Institute
Volume96
Issue number14
DOIs
Publication statusPublished - 21 Jul 2004

Keywords

  • Adult
  • Antineoplastic Combined Chemotherapy Protocols
  • Breast Neoplasms
  • Chemotherapy, Adjuvant
  • Cyclophosphamide
  • Disease-Free Survival
  • Doxorubicin
  • Drug Administration Schedule
  • Female
  • Fluorouracil
  • Granulocyte Colony-Stimulating Factor
  • Hematopoietic Stem Cells
  • Humans
  • Leukapheresis
  • Lymphatic Metastasis
  • Mastectomy
  • Mastectomy, Segmental
  • Methotrexate
  • Middle Aged
  • Prospective Studies
  • Radiotherapy, Adjuvant
  • Recombinant Proteins
  • Risk Assessment
  • Risk Factors
  • Survival Analysis
  • Transplantation, Autologous
  • Treatment Outcome

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