Cooperative Binding

Melanie I. Stefan*, Nicolas Le Novere

*Corresponding author for this work

Research output: Contribution to journalLiterature reviewpeer-review

Abstract / Description of output

Molecular binding is an interaction between molecules that results in a stable association between those molecules. Cooperative binding occurs if the number of binding sites of a macromolecule that are occupied by a specific type of ligand is a nonlinear function of this ligand's concentration. This can be due, for instance, to an affinity for the ligand that depends on the amount of ligand bound. Cooperativity can be positive (supralinear) or negative (infralinear). Cooperative binding is most often observed in proteins, but nucleic acids can also exhibit cooperative binding, for instance of transcription factors. Cooperative binding has been shown to be the mechanism underlying a large range of biochemical and physiological processes.

Original languageEnglish
Article number1003106
Number of pages6
JournalPLoS Computational Biology
Volume9
Issue number6
DOIs
Publication statusPublished - 27 Jun 2013

Keywords / Materials (for Non-textual outputs)

  • L-THREONINE DEAMINASE
  • ALLOSTERIC TRANSITIONS
  • RECEPTOR COMPLEXES
  • ESCHERICHIA-COLI
  • PLAUSIBLE MODEL
  • LIGAND-BINDING
  • PROTEINS
  • MECHANISM
  • REPRESSOR
  • ACETYLCHOLINE

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