Cooperative study on the value of long term anticoagulation in patients with stroke and non-rheumatic atrial fibrillation

J Lodder, M S Dennis, L Van Raak, L N Jones, C P Warlow

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

The benefits of long term anticoagulant treatment of patients with non-rheumatic atrial fibrillation and cerebral infarction were studied by comparing two series of patients with stroke from centres with different policies on anticoagulant treatment. The long term prognosis of 50 patients from the Oxfordshire community stroke project, who did not receive anticoagulants, was compared with that of 70 similar patients from Maastricht, who were treated with anticoagulants. After a mean follow up of 27 months there was no significant difference in either the rate of survival or the rate of recurrent stroke between the two groups. These data suggest that any benefit of anticoagulation is modest. A large randomised trial is planned to establish whether long term anticoagulant treatment is of value and, if so, to what extent.

Original languageEnglish
Pages (from-to)1435-8
Number of pages4
JournalBritish medical journal (Clinical research ed.)
Volume296
Issue number6634
Publication statusPublished - 21 May 1988

Keywords / Materials (for Non-textual outputs)

  • Aged
  • Aged, 80 and over
  • Anticoagulants
  • Atrial Fibrillation
  • Cerebrovascular Disorders
  • Humans
  • Prospective Studies
  • Recurrence
  • Time Factors

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