Coordination of cell polarization and migration by the Rho family GTPases requires Src tyrosine kinase activity

P Timpson; G E Jones; M C Frame; V G Brunton

Coordination of cell polarization and migration by the Rho family GTPases requires Src tyrosine kinase activity

P Timpson, G E Jones, M C Frame, V G Brunton

Research output: Contribution to journal › Article › peer-review

Abstract / Description of output

The ability of a cell to polarize and move is governed by remodeling of the cellular adhesion/cytoskeletal network that is in turn controlled by the Rho family of small GTPases. However, it is not known what signals lie downstream of Rac1 and Cdc42 during peripheral actin and adhesion remodeling that is required for directional migration.

Original language	English
Pages (from-to)	1836-46
Number of pages	11
Journal	Current biology : CB
Volume	11
Issue number	23
Publication status	Published - 27 Nov 2001

Keywords / Materials (for Non-textual outputs)

Biological Transport
Cell Adhesion
Cell Movement
Cell Polarity
Focal Adhesion Protein-Tyrosine Kinases
Phosphorylation
Protein-Tyrosine Kinases
rho GTP-Binding Proteins
src-Family Kinases

Cite this

@article{ae69256cdbbb45289380de8155381efc,

title = "Coordination of cell polarization and migration by the Rho family GTPases requires Src tyrosine kinase activity",

abstract = "The ability of a cell to polarize and move is governed by remodeling of the cellular adhesion/cytoskeletal network that is in turn controlled by the Rho family of small GTPases. However, it is not known what signals lie downstream of Rac1 and Cdc42 during peripheral actin and adhesion remodeling that is required for directional migration.",

keywords = "Biological Transport, Cell Adhesion, Cell Movement, Cell Polarity, Focal Adhesion Protein-Tyrosine Kinases, Phosphorylation, Protein-Tyrosine Kinases, rho GTP-Binding Proteins, src-Family Kinases",

author = "P Timpson and Jones, {G E} and Frame, {M C} and Brunton, {V G}",

year = "2001",

month = nov,

day = "27",

language = "English",

volume = "11",

pages = "1836--46",

journal = "Current biology : CB",

issn = "0960-9822",

publisher = "Cell Press",

number = "23",

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TY - JOUR

T1 - Coordination of cell polarization and migration by the Rho family GTPases requires Src tyrosine kinase activity

AU - Timpson, P

AU - Jones, G E

AU - Frame, M C

AU - Brunton, V G

PY - 2001/11/27

Y1 - 2001/11/27

N2 - The ability of a cell to polarize and move is governed by remodeling of the cellular adhesion/cytoskeletal network that is in turn controlled by the Rho family of small GTPases. However, it is not known what signals lie downstream of Rac1 and Cdc42 during peripheral actin and adhesion remodeling that is required for directional migration.

AB - The ability of a cell to polarize and move is governed by remodeling of the cellular adhesion/cytoskeletal network that is in turn controlled by the Rho family of small GTPases. However, it is not known what signals lie downstream of Rac1 and Cdc42 during peripheral actin and adhesion remodeling that is required for directional migration.

KW - Biological Transport

KW - Cell Adhesion

KW - Cell Movement

KW - Cell Polarity

KW - Focal Adhesion Protein-Tyrosine Kinases

KW - Phosphorylation

KW - Protein-Tyrosine Kinases

KW - rho GTP-Binding Proteins

KW - src-Family Kinases

M3 - Article

C2 - 11728306

SN - 0960-9822

VL - 11

SP - 1836

EP - 1846

JO - Current biology : CB

JF - Current biology : CB

IS - 23

ER -

Coordination of cell polarization and migration by the Rho family GTPases requires Src tyrosine kinase activity

Abstract / Description of output

Keywords / Materials (for Non-textual outputs)

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Cite this