COPD AND SYSTEMIC INFLAMMATION: MYTH OR REALITY? REALITY

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Chronic obstructive pulmonary disease (COPD) is an inflammatory condition of the lungs which has recently been recognised as a systemic disorder with important extra-pulmonary manifestations. It is thought that systemic inflammation is the underlying mechanism which results in these systemic manifestations. A systemic inflammatory response is known to occur in COPD patients and involves mobilisation and activation of inflammatory cells into the circulation, increases in acute phase proteins and in circulating inflammatory mediators. The mechanisms responsible for the systemic inflammatory response in COPD are still not fully determined. A number of mechanisms have been proposed such as smoking, spill over from the lungs into the systemic circulation, hyperinflation, tissue hypoxia, inflammatory mediator release from skeletal muscles, and a response of the bone marrow. It is likely that systemic inflammation is a major contributor to the pathobiology of the extra-pulmonary effects of COPD leading to comorbidities, functional impairment, worsening mortality.

Original languageEnglish
Title of host publicationCOPD IS/IS NOT A SYSTEMIC DISEASE?
EditorsCF Donner
Place of PublicationHAUPPAUGE
PublisherNova Science Publishers Inc
Pages31-39
Number of pages9
ISBN (Print)978-1-60876-051-0
Publication statusPublished - 2010
EventExpert Opinion Consensus/Dissensus Seminar COPD is/is not a systemic disease - Venice
Duration: 13 Nov 200814 Nov 2008

Conference

ConferenceExpert Opinion Consensus/Dissensus Seminar COPD is/is not a systemic disease
CityVenice
Period13/11/0814/11/08

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