Copper-Bisphosphine-Initiated Pentafluorophenylation of Aldehydes and Ketones

Samantha Brogan; Neil B. Carter; Hon Wai Lam

doi:10.1055/s-0029-1219159

Copper-Bisphosphine-Initiated Pentafluorophenylation of Aldehydes and Ketones

Samantha Brogan, Neil B. Carter, Hon Wai Lam

Research output: Contribution to journal › Article › peer-review

Abstract / Description of output

In the presence of substoichiometric quantities of a copper-bisphosphine complex, a variety of aldehydes and reactive ketones undergo pentafluorophenylation using pentafluorophenyltrimethylsilane.

Original language	English
Pages (from-to)	615-617
Number of pages	3
Journal	Accounts and Rapid Communications in Chemical Synthesis (SYNLETT)
Issue number	4
DOIs	https://doi.org/10.1055/s-0029-1219159
Publication status	Published - Mar 2010

Keywords / Materials (for Non-textual outputs)

aldehydes
copper
ketones
nucleophilic addition
pentafluorophenylation
MEDICINAL CHEMISTRY
TRIFLUOROMETHYLATION
FLUORINE
PENTAFLUOROPHENYLTRIMETHYLSILANE
ACTIVATION
AMINES
ACID
NMR

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10.1055/s-0029-1219159

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@article{2d3ab00ceb174085b3531ca6be997020,

title = "Copper-Bisphosphine-Initiated Pentafluorophenylation of Aldehydes and Ketones",

abstract = "In the presence of substoichiometric quantities of a copper-bisphosphine complex, a variety of aldehydes and reactive ketones undergo pentafluorophenylation using pentafluorophenyltrimethylsilane.",

keywords = "aldehydes, copper, ketones, nucleophilic addition, pentafluorophenylation, MEDICINAL CHEMISTRY, TRIFLUOROMETHYLATION, FLUORINE, PENTAFLUOROPHENYLTRIMETHYLSILANE, ACTIVATION, AMINES, ACID, NMR",

author = "Samantha Brogan and Carter, {Neil B.} and Lam, {Hon Wai}",

year = "2010",

month = mar,

doi = "10.1055/s-0029-1219159",

language = "English",

pages = "615--617",

journal = "Accounts and Rapid Communications in Chemical Synthesis (SYNLETT)",

issn = "0936-5214",

publisher = "Thieme Gruppe",

number = "4",

}

TY - JOUR

T1 - Copper-Bisphosphine-Initiated Pentafluorophenylation of Aldehydes and Ketones

AU - Brogan, Samantha

AU - Carter, Neil B.

AU - Lam, Hon Wai

PY - 2010/3

Y1 - 2010/3

N2 - In the presence of substoichiometric quantities of a copper-bisphosphine complex, a variety of aldehydes and reactive ketones undergo pentafluorophenylation using pentafluorophenyltrimethylsilane.

AB - In the presence of substoichiometric quantities of a copper-bisphosphine complex, a variety of aldehydes and reactive ketones undergo pentafluorophenylation using pentafluorophenyltrimethylsilane.

KW - aldehydes

KW - copper

KW - ketones

KW - nucleophilic addition

KW - pentafluorophenylation

KW - MEDICINAL CHEMISTRY

KW - TRIFLUOROMETHYLATION

KW - FLUORINE

KW - PENTAFLUOROPHENYLTRIMETHYLSILANE

KW - ACTIVATION

KW - AMINES

KW - ACID

KW - NMR

U2 - 10.1055/s-0029-1219159

DO - 10.1055/s-0029-1219159

M3 - Article

SN - 0936-5214

SP - 615

EP - 617

JO - Accounts and Rapid Communications in Chemical Synthesis (SYNLETT)

JF - Accounts and Rapid Communications in Chemical Synthesis (SYNLETT)

IS - 4

ER -

Copper-Bisphosphine-Initiated Pentafluorophenylation of Aldehydes and Ketones

Abstract / Description of output

Keywords / Materials (for Non-textual outputs)

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