Copper Catalysis in Living Systems and In Situ Drug Synthesis

Jessica Clavadetscher, Scott Hoffmann, Annamaria Lilienkampf, Logan Mackay, Rahimi M. Yusop, Sebastien A. Rider, John J. Mullins, Mark Bradley

Research output: Contribution to journalArticlepeer-review

Abstract

The copper‐catalyzed azide–alkyne cycloaddition (CuAAC) reaction has proven to be a pivotal advance in chemical ligation strategies with applications ranging from polymer fabrication to bioconjugation. However, application in vivo has been limited by the inherent toxicity of the copper catalyst. Herein, we report the application of heterogeneous copper catalysts in azide–alkyne cycloaddition processes in biological systems ranging from cells to zebrafish, with reactions spanning from fluorophore activation to the first reported in situ generation of a triazole‐containing anticancer agent from two benign components, opening up many new avenues of exploration for CuAAC chemistry.
Original languageEnglish
Pages (from-to)15662-15666
Number of pages5
JournalAngewandte Chemie International Edition
Volume55
Issue number50
Early online date15 Nov 2016
DOIs
Publication statusPublished - 12 Dec 2016

Fingerprint

Dive into the research topics of 'Copper Catalysis in Living Systems and In Situ Drug Synthesis'. Together they form a unique fingerprint.

Cite this