Projects per year
Abstract
The copper‐catalyzed azide–alkyne cycloaddition (CuAAC) reaction has proven to be a pivotal advance in chemical ligation strategies with applications ranging from polymer fabrication to bioconjugation. However, application in vivo has been limited by the inherent toxicity of the copper catalyst. Herein, we report the application of heterogeneous copper catalysts in azide–alkyne cycloaddition processes in biological systems ranging from cells to zebrafish, with reactions spanning from fluorophore activation to the first reported in situ generation of a triazole‐containing anticancer agent from two benign components, opening up many new avenues of exploration for CuAAC chemistry.
Original language | English |
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Pages (from-to) | 15662-15666 |
Number of pages | 5 |
Journal | Angewandte Chemie International Edition |
Volume | 55 |
Issue number | 50 |
Early online date | 15 Nov 2016 |
DOIs | |
Publication status | Published - 12 Dec 2016 |
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Dive into the research topics of 'Copper Catalysis in Living Systems and In Situ Drug Synthesis'. Together they form a unique fingerprint.Projects
- 1 Finished
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In vivo, in situ chemical ignition and activity control (037427/1)
Bradley, M.
1/11/15 → 31/10/18
Project: Research