Cotranscriptional events in eukaryotic ribosome synthesis

Tomasz W. Turowski, David Tollervey*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Eukaryotic ribosomes are synthesized in a complex, multistep pathway. This begins with transcription of the rDNA genes by a specialized RNA polymerase, accompanied by the cotranscriptional binding of large numbers of ribosome synthesis factors, small nucleolar RNAs and ribosomal proteins. Cleavage of the nascent transcript releases the early pre-40S and pre-60S particles, which acquire export competence in the nucleoplasm prior to translocation through the nuclear pore complexes and final maturation to functional ribosomal subunits in the cytoplasm. This review will focus on the many and complex interactions occurring during pre-rRNA synthesis, particularly in budding yeast in which the pathway is best understood.

Original languageEnglish
JournalWiley Interdisciplinary Reviews: RNA
Early online date29 Aug 2014
DOIs
Publication statusPublished - 1 Sep 2014

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