Coupled changes in brain white matter microstructure and fluid intelligence in later life

Stuart J. Ritchie, Mark E. Bastin, Elliot M Tucker-Drob, Susana Munoz-Maniega, Laura E. Engelhardt, Simon R. Cox, Natalie A. Royle, Alan J. Gow, Janie Corley, Alison Pattie, Adele M. Taylor, Maria del C. Valdes Hernandez, John M. Starr, Joanna M. Wardlaw, Ian Deary

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Understanding aging-related cognitive decline is of growing importance in aging societies, but relatively little is known about its neural substrates. Measures of white matter microstructure are known to correlate cross-sectionally with cognitive ability measures, but only a few small studies have tested for longitudinal relations among these variables. We tested whether there were coupled changes in brain white matter microstructure indexed by fractional anisotropy (FA) and three broad cognitive domains (fluid intelligence, processing speed, and memory) in a large cohort of human participants with longitudinal diffusion tensor MRI and detailed cognitive data taken at ages 73 years (n = 731) and 76 years (n = 488). Longitudinal changes in white matter microstructure were coupled with changes in fluid intelligence, but not with processing speed or memory. Individuals with higher baseline white matter FA showed less subsequent decline in processing speed. Our results provide evidence for a longitudinal link between changes in white matter microstructure and aging-related cognitive decline during the eighth decade of life. They are consistent with theoretical perspectives positing that a corticocortical “disconnection” partly explains cognitive aging.
Original languageEnglish
Pages (from-to)8672-8682
Number of pages11
JournalThe Journal of Neuroscience
Issue number22
Publication statusPublished - 3 Jun 2015

Keywords / Materials (for Non-textual outputs)

  • Intelligence
  • Ageing
  • White matter
  • Diffusion tensor imaging
  • Longitudinal


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