Coupling the initiation of chromosome replication to cell size in Escherichia coli

William D Donachie, Garry W Blakely

Research output: Contribution to journalArticlepeer-review

Abstract

Bacterial cells change size dramatically with change in growth rate, but the ratio between cell volume and the number of copies of the origin of chromosome replication (oriC) is roughly constant at the time of initiation of DNA replication at almost all growth rates. Recent research on the inactivation of initiator protein (DnaA) and depletion of DnaA pools by the high-affinity DnaA-binding locus datA allows us to propose a simple model to explain the long-standing question of how Escherichia coli couples DNA replication to cell size.
Original languageEnglish
Pages (from-to)146-50
Number of pages5
JournalCurrent Opinion in Microbiology
Volume6
Issue number2
Publication statusPublished - 2003

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