COVID-19 among adults living with HIV: correlates of mortality among public sector healthcare users in Western Cape, South Africa

Reshma Kassanjee*, Mary Ann Davies, Olina Ngwenya, Richard Osei-Yeboah, Theuns Jacobs, Erna Morden, Venessa Timmerman, Stefan Britz, Marc Mendelson, Jantjie Taljaard, Julien Riou, Andrew Boulle, Nicki Tiffin, Nesbert Zinyakatira

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Introduction: While a large proportion of people with HIV (PWH) have experienced SARS-CoV-2 infections, there is uncertainty about the role of HIV disease severity on COVID-19 outcomes, especially in lower-income settings. We studied the association of mortality with characteristics of HIV severity and management, and vaccination, among adult PWH. Methods: We analysed observational cohort data on all PWH aged ≥15 years experiencing a diagnosed SARS-CoV-2 infection (until March 2022), who accessed public sector healthcare in the Western Cape province of South Africa. Logistic regression was used to study the association of mortality with evidence of antiretroviral therapy (ART) collection, time since first HIV evidence, CD4 cell count, viral load (among those with evidence of ART collection) and COVID-19 vaccination, adjusting for demographic characteristics, comorbidities, admission pressure, location and time period. Results: Mortality occurred in 5.7% (95% CI: 5.3,6.0) of 17,831 first-diagnosed infections. Higher mortality was associated with lower recent CD4, no evidence of ART collection, high or unknown recent viral load and recent first HIV evidence, differentially by age. Vaccination was protective. The burden of comorbidities was high, and tuberculosis (especially more recent episodes of tuberculosis), chronic kidney disease, diabetes and hypertension were associated with higher mortality, more strongly in younger adults. Conclusions: Mortality was strongly associated with suboptimal HIV control, and the prevalence of these risk factors increased in later COVID-19 waves. It remains a public health priority to ensure PWH are on suppressive ART and vaccinated, and manage any disruptions in care that occurred during the pandemic. The diagnosis and management of comorbidities, including for tuberculosis, should be optimized.

Original languageEnglish
Article numbere26104
JournalJournal of the International AIDS Society
Issue number6
Publication statusPublished - 20 Jun 2023

Keywords / Materials (for Non-textual outputs)

  • CD4 count
  • COVID-19
  • HIV
  • mortality
  • SARS-CoV-2
  • South Africa


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