CR1 Knops blood group alleles are not associated with severe malaria in the Gambia

P A Zimmerman, J Fitness, J M Moulds, D T McNamara, L J Kasehagen, J Alexandra Rowe, A V S Hill

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

The Knops blood group antigen erythrocyte polymorphisms have been associated with reduced falciparum malaria-based in vitro rosette formation (putative malaria virulence factor). Having previously identified single-nucleotide polymorphisms (SNPs) in the human complement receptor 1 (CR1/CD35) gene underlying the Knops antithetical antigens Sl1/Sl2 and McC(a)/McC(b), we have now performed genotype comparisons to test associations between these two molecular variants and severe malaria in West African children living in the Gambia. While SNPs associated with Sl:2 and McC(b+) were equally distributed among malaria-infected children with severe malaria and control children not infected with malaria parasites, high allele frequencies for Sl 2 (0.800, 1,365/1,706) and McC(b) (0.385, 658/1706) were observed. Further, when compared to the Sl 1/McC(a) allele observed in all populations, the African Sl 2/McC(b) allele appears to have evolved as a result of positive selection (modified Nei-Gojobori test Ka-Ks/s.e.=1.77, P-value
Original languageEnglish
Pages (from-to)368-73
Number of pages6
JournalGenes and Immunity
Volume4
Issue number5
DOIs
Publication statusPublished - 2003

Keywords / Materials (for Non-textual outputs)

  • malaria
  • blood groups
  • single-nucleotide polymorphisms
  • complement receptor 1 (CR1)
  • evolution

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