CRASH-2 (Clinical Randomisation of an Antifibrinolytic in Significant Haemorrhage) intracranial bleeding study: the effect of tranexamic acid in traumatic brain injury--a nested randomised, placebo-controlled trial

P Perel, R Al-Shahi Salman, T Kawahara, Z Morris, D Prieto-Merino, I Roberts, P Sandercock, H Shakur, J Wardlaw

Research output: Contribution to journalArticlepeer-review

Abstract

Tranexamic acid (TXA) has been shown to reduce blood loss in surgical patients and the risk of death in patients with traumatic bleeding, with no apparent increase in vascular occlusive events. These findings raise the possibility that it might also be effective in traumatic brain injury (TBI).
Original languageEnglish
Pages (from-to)iii-xii, 1-54
JournalHealth Technology Assessment
Volume16
Issue number13
DOIs
Publication statusPublished - 2012

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