CRASH-2 (Clinical Randomisation of an Antifibrinolytic in Significant Haemorrhage) intracranial bleeding study: the effect of tranexamic acid in traumatic brain injury--a nested randomised, placebo-controlled trial

P Perel; R Al-Shahi Salman; T Kawahara; Z Morris; D Prieto-Merino; I Roberts; P Sandercock; H Shakur; J Wardlaw

doi:10.3310/hta16130

CRASH-2 (Clinical Randomisation of an Antifibrinolytic in Significant Haemorrhage) intracranial bleeding study: the effect of tranexamic acid in traumatic brain injury--a nested randomised, placebo-controlled trial

P Perel, R Al-Shahi Salman, T Kawahara, Z Morris, D Prieto-Merino, I Roberts, P Sandercock, H Shakur, J Wardlaw

Research output: Contribution to journal › Article › peer-review

Abstract

Tranexamic acid (TXA) has been shown to reduce blood loss in surgical patients and the risk of death in patients with traumatic bleeding, with no apparent increase in vascular occlusive events. These findings raise the possibility that it might also be effective in traumatic brain injury (TBI).

Original language	English
Pages (from-to)	iii-xii, 1-54
Journal	Health Technology Assessment
Volume	16
Issue number	13
DOIs	https://doi.org/10.3310/hta16130
Publication status	Published - 2012

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Perel, P., Salman, R. A-S., Kawahara, T., Morris, Z., Prieto-Merino, D., Roberts, I., Sandercock, P., Shakur, H., & Wardlaw, J. (2012). CRASH-2 (Clinical Randomisation of an Antifibrinolytic in Significant Haemorrhage) intracranial bleeding study: the effect of tranexamic acid in traumatic brain injury--a nested randomised, placebo-controlled trial. Health Technology Assessment, 16(13), iii-xii, 1-54. https://doi.org/10.3310/hta16130

Perel, P ; Salman, R Al-Shahi ; Kawahara, T ; Morris, Z ; Prieto-Merino, D ; Roberts, I ; Sandercock, P ; Shakur, H ; Wardlaw, J. / CRASH-2 (Clinical Randomisation of an Antifibrinolytic in Significant Haemorrhage) intracranial bleeding study: the effect of tranexamic acid in traumatic brain injury--a nested randomised, placebo-controlled trial. In: Health Technology Assessment. 2012 ; Vol. 16, No. 13. pp. iii-xii, 1-54.

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title = "CRASH-2 (Clinical Randomisation of an Antifibrinolytic in Significant Haemorrhage) intracranial bleeding study: the effect of tranexamic acid in traumatic brain injury--a nested randomised, placebo-controlled trial",

abstract = "Tranexamic acid (TXA) has been shown to reduce blood loss in surgical patients and the risk of death in patients with traumatic bleeding, with no apparent increase in vascular occlusive events. These findings raise the possibility that it might also be effective in traumatic brain injury (TBI).",

author = "P Perel and Salman, {R Al-Shahi} and T Kawahara and Z Morris and D Prieto-Merino and I Roberts and P Sandercock and H Shakur and J Wardlaw",

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Perel, P, Salman, RA-S, Kawahara, T, Morris, Z, Prieto-Merino, D, Roberts, I, Sandercock, P, Shakur, H & Wardlaw, J 2012, 'CRASH-2 (Clinical Randomisation of an Antifibrinolytic in Significant Haemorrhage) intracranial bleeding study: the effect of tranexamic acid in traumatic brain injury--a nested randomised, placebo-controlled trial', Health Technology Assessment, vol. 16, no. 13, pp. iii-xii, 1-54. https://doi.org/10.3310/hta16130

CRASH-2 (Clinical Randomisation of an Antifibrinolytic in Significant Haemorrhage) intracranial bleeding study: the effect of tranexamic acid in traumatic brain injury--a nested randomised, placebo-controlled trial. / Perel, P; Salman, R Al-Shahi; Kawahara, T; Morris, Z; Prieto-Merino, D; Roberts, I; Sandercock, P; Shakur, H; Wardlaw, J.

In: Health Technology Assessment, Vol. 16, No. 13, 2012, p. iii-xii, 1-54.

Research output: Contribution to journal › Article › peer-review

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Perel P, Salman RA-S, Kawahara T, Morris Z, Prieto-Merino D, Roberts I et al. CRASH-2 (Clinical Randomisation of an Antifibrinolytic in Significant Haemorrhage) intracranial bleeding study: the effect of tranexamic acid in traumatic brain injury--a nested randomised, placebo-controlled trial. Health Technology Assessment. 2012;16(13):iii-xii, 1-54. https://doi.org/10.3310/hta16130