Projects per year
Abstract
Rapid evolution in transgenic (Tg) mouse technology now permits cell-specific and temporal control of fluorescent cell-labeling and gene inactivation. Here, we discuss the principal strategies that have been utilized to target, label, and manipulate hepatic nonparenchymal cells, with emphasis on the utility of constitutive and inducible Cre-lox systems. We summarize key findings of studies employing Tg technology to target hepatic stellate cells, myofibroblasts, liver sinusoidal endothelial cells, and macrophages to illustrate the power of these approaches in identifying cell-specific molecular mechanisms critical to the pathophysiology of liver disease. Increasing adoption of Tg techniques will help to answer fundamental questions regarding the pathogenesis of hepatic diseases and provide the mechanistic rationale to allow identification of novel drug targets, ultimately translating into effective therapies for patients with liver disease.
Original language | English |
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Pages (from-to) | 2091-2099 |
Number of pages | 9 |
Journal | Hepatology |
Volume | 61 |
Issue number | 6 |
Early online date | 21 Nov 2014 |
DOIs | |
Publication status | Published - Jun 2015 |
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Dive into the research topics of 'Cre-ativity in the liver: Transgenic approaches to targeting hepatic nonparenchymal cells'. Together they form a unique fingerprint.Projects
- 2 Finished
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An intravital imaging approach to elucidate novel mechanisms of organ fibrosis and repair
Henderson, N. (Principal Investigator)
1/08/14 → 31/01/20
Project: Research
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CRTF for Stephen Greenhalgh: Investigation of the role of
Greenhalgh, S. (Principal Investigator)
5/02/14 → 19/03/17
Project: Research