Critical role of c-jun (NH2) terminal kinase in paracetamol- induced acute liver failure

Neil C Henderson; Katharine J Pollock; John Frew; Alison C Mackinnon; Richard A Flavell; Roger J Davis; Tariq Sethi; Kenneth J Simpson

doi:10.1136/gut.2006.104372

Critical role of c-jun (NH2) terminal kinase in paracetamol- induced acute liver failure

Neil C Henderson, Katharine J Pollock, John Frew, Alison C Mackinnon, Richard A Flavell, Roger J Davis, Tariq Sethi, Kenneth J Simpson

Research output: Contribution to journal › Article › peer-review

Abstract / Description of output

Acute hepatic failure secondary to paracetamol poisoning is associated with high mortality. C-jun (NH2) terminal kinase (JNK) is a member of the mitogen-activated protein kinase family and is a key intracellular signalling molecule involved in controlling the fate of cells.

Original language	English
Pages (from-to)	982-90
Number of pages	9
Journal	Gut
Volume	56
Issue number	7
DOIs	https://doi.org/10.1136/gut.2006.104372
Publication status	Published - 2007

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10.1136/gut.2006.104372

Critical role of c-jun (NH2) terminal kinase in paracetamol- induced acute liver failureFinal published version, 2.57 MB

http://gut.bmj.com/content/56/7/982

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title = "Critical role of c-jun (NH2) terminal kinase in paracetamol- induced acute liver failure",

abstract = "Acute hepatic failure secondary to paracetamol poisoning is associated with high mortality. C-jun (NH2) terminal kinase (JNK) is a member of the mitogen-activated protein kinase family and is a key intracellular signalling molecule involved in controlling the fate of cells.",

author = "Henderson, {Neil C} and Pollock, {Katharine J} and John Frew and Mackinnon, {Alison C} and Flavell, {Richard A} and Davis, {Roger J} and Tariq Sethi and Simpson, {Kenneth J}",

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T1 - Critical role of c-jun (NH2) terminal kinase in paracetamol- induced acute liver failure

AU - Henderson, Neil C

AU - Pollock, Katharine J

AU - Frew, John

AU - Mackinnon, Alison C

AU - Flavell, Richard A

AU - Davis, Roger J

AU - Sethi, Tariq

AU - Simpson, Kenneth J

PY - 2007

Y1 - 2007

N2 - Acute hepatic failure secondary to paracetamol poisoning is associated with high mortality. C-jun (NH2) terminal kinase (JNK) is a member of the mitogen-activated protein kinase family and is a key intracellular signalling molecule involved in controlling the fate of cells.

AB - Acute hepatic failure secondary to paracetamol poisoning is associated with high mortality. C-jun (NH2) terminal kinase (JNK) is a member of the mitogen-activated protein kinase family and is a key intracellular signalling molecule involved in controlling the fate of cells.

U2 - 10.1136/gut.2006.104372

DO - 10.1136/gut.2006.104372

M3 - Article

C2 - 17185352

SN - 0017-5749

VL - 56

SP - 982

EP - 990

JO - Gut

JF - Gut

IS - 7

ER -

Critical role of c-jun (NH2) terminal kinase in paracetamol- induced acute liver failure

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