Cross-species considerations in models of neurodevelopmental disorders

Sally M. Till; Raven D.L. Hickson; Peter C. Kind

doi:10.1016/j.tins.2021.12.005

Cross-species considerations in models of neurodevelopmental disorders

Sally M. Till^*, Raven D.L. Hickson, Peter C. Kind

^*Corresponding author for this work

Research output: Contribution to journal › Short survey › peer-review

Abstract / Description of output

Advances in genetic technologies have facilitated the development of new animal models of neurodevelopmental disorders (NDDs), enabling cross-species validation of disease-related phenotypes and exploration of species-specific behaviours. In a recent study, Berg et al. used a rat model of Angelman Syndrome (AS) to identify Ube3a-dependent social behaviours, highlighting potential cross-species convergence and divergence between rodent models.

Original language	English
Pages (from-to)	171-172
Number of pages	2
Journal	Trends in Neurosciences
Volume	45
Issue number	3
Early online date	5 Jan 2022
DOIs	https://doi.org/10.1016/j.tins.2021.12.005
Publication status	Published - Mar 2022

Keywords / Materials (for Non-textual outputs)

Angelman Syndrome
autism
convergence, social play
mouse model
rat model

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10.1016/j.tins.2021.12.005

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title = "Cross-species considerations in models of neurodevelopmental disorders",

abstract = "Advances in genetic technologies have facilitated the development of new animal models of neurodevelopmental disorders (NDDs), enabling cross-species validation of disease-related phenotypes and exploration of species-specific behaviours. In a recent study, Berg et al. used a rat model of Angelman Syndrome (AS) to identify Ube3a-dependent social behaviours, highlighting potential cross-species convergence and divergence between rodent models.",

keywords = "Angelman Syndrome, autism, convergence, social play, mouse model, rat model",

author = "Till, {Sally M.} and Hickson, {Raven D.L.} and Kind, {Peter C.}",

note = "Funding Information: We thank members of the Simons Initiative for the Developing Brain (SIDB) for many helpful discussions. The authors are funded by SIDB ( SFARI 52085 ) and the Patrick Wild Centre . Publisher Copyright: {\textcopyright} 2021 Elsevier Ltd",

year = "2022",

month = mar,

doi = "10.1016/j.tins.2021.12.005",

language = "English",

volume = "45",

pages = "171--172",

journal = "Trends in Neurosciences",

issn = "0166-2236",

publisher = "Elsevier Science",

number = "3",

}

TY - JOUR

T1 - Cross-species considerations in models of neurodevelopmental disorders

AU - Till, Sally M.

AU - Hickson, Raven D.L.

AU - Kind, Peter C.

N1 - Funding Information: We thank members of the Simons Initiative for the Developing Brain (SIDB) for many helpful discussions. The authors are funded by SIDB ( SFARI 52085 ) and the Patrick Wild Centre . Publisher Copyright: © 2021 Elsevier Ltd

PY - 2022/3

Y1 - 2022/3

N2 - Advances in genetic technologies have facilitated the development of new animal models of neurodevelopmental disorders (NDDs), enabling cross-species validation of disease-related phenotypes and exploration of species-specific behaviours. In a recent study, Berg et al. used a rat model of Angelman Syndrome (AS) to identify Ube3a-dependent social behaviours, highlighting potential cross-species convergence and divergence between rodent models.

AB - Advances in genetic technologies have facilitated the development of new animal models of neurodevelopmental disorders (NDDs), enabling cross-species validation of disease-related phenotypes and exploration of species-specific behaviours. In a recent study, Berg et al. used a rat model of Angelman Syndrome (AS) to identify Ube3a-dependent social behaviours, highlighting potential cross-species convergence and divergence between rodent models.

KW - Angelman Syndrome

KW - autism

KW - convergence, social play

KW - mouse model

KW - rat model

UR - http://www.scopus.com/inward/record.url?scp=85122303580&partnerID=8YFLogxK

U2 - 10.1016/j.tins.2021.12.005

DO - 10.1016/j.tins.2021.12.005

M3 - Short survey

C2 - 34998618

AN - SCOPUS:85122303580

SN - 0166-2236

VL - 45

SP - 171

EP - 172

JO - Trends in Neurosciences

JF - Trends in Neurosciences

IS - 3

ER -

Cross-species considerations in models of neurodevelopmental disorders

Abstract / Description of output

Keywords / Materials (for Non-textual outputs)

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