TY - JOUR
T1 - Cross-species models of human melanoma
AU - van der Weyden, Louise
AU - Patton, Eleanor
AU - Wood, Geoffrey A.
AU - Foote, Alastair
AU - Brenn, Thomas
AU - Arends, Mark
AU - Adams, David J
PY - 2016/1/1
Y1 - 2016/1/1
N2 - Although transformation of melanocytes to melanoma is rare, the rapid growth, systemic spread, as well as the chemoresistance of melanoma present significant challenges for patient care. Here we review animal models of melanoma, including murine, canine, equine, and zebrafish models, and detail the immense contribution these models have made to our knowledge of human melanoma development, and to melanocyte biology. We also highlight the opportunities for cross-species comparative genomic studies of melanoma to identify the key molecular events that drive this complex disease
AB - Although transformation of melanocytes to melanoma is rare, the rapid growth, systemic spread, as well as the chemoresistance of melanoma present significant challenges for patient care. Here we review animal models of melanoma, including murine, canine, equine, and zebrafish models, and detail the immense contribution these models have made to our knowledge of human melanoma development, and to melanocyte biology. We also highlight the opportunities for cross-species comparative genomic studies of melanoma to identify the key molecular events that drive this complex disease
U2 - 10.1002/path.4632
DO - 10.1002/path.4632
M3 - Article
SN - 0022-3417
JO - The Journal of Pathology
JF - The Journal of Pathology
ER -