Cross-species models of human melanoma

Louise van der Weyden, Eleanor Patton, Geoffrey A. Wood, Alastair Foote, Thomas Brenn, Mark Arends, David J Adams

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Although transformation of melanocytes to melanoma is rare, the rapid growth, systemic spread, as well as the chemoresistance of melanoma present significant challenges for patient care. Here we review animal models of melanoma, including murine, canine, equine, and zebrafish models, and detail the immense contribution these models have made to our knowledge of human melanoma development, and to melanocyte biology. We also highlight the opportunities for cross-species comparative genomic studies of melanoma to identify the key molecular events that drive this complex disease
Original languageEnglish
JournalThe Journal of Pathology
Early online date10 Sept 2015
Publication statusPublished - 1 Jan 2016


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