Crossed cerebral lateralization for verbal and visuo-spatial function in a pair of handedness discordant monozygotic twins: MRI and fMRI brain imaging

Silke Lux, Simon Keller, Clare Mackay, George Ebers, John C Marshall, Lynne Cherkas, Roozbeh Rezaie, Neil Roberts, Gereon R Fink, Jennifer M Gurd

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

To examine the nature of hemispheric lateralization for neural processes underlying verbal fluency and visuo-spatial attention, we investigated a single pair of handedness discordant monozygotic (MzHd) twins. Imaging of the brain was undertaken using magnetic resonance imaging (MRI) and functional magnetic resonance imaging (fMRI) in combination with manual performance tasks. The twins were discordant for MRI anatomical asymmetries of the pars triangularis and planum temporale, whose asymmetry was consistent with verbal laterality on fMRI. Thus, the right-handed twin had left lateralized verbal with right lateralized visuo-spatial attention, while the left-handed twin had right lateralized verbal with left lateralized visuo-spatial activation; these data lend further support for to the conclusions of Sommer et al.

Original languageEnglish
Pages (from-to)235-48
Number of pages14
JournalJournal of Anatomy
Volume212
Issue number3
DOIs
Publication statusPublished - Mar 2008

Keywords / Materials (for Non-textual outputs)

  • Brain
  • Female
  • Functional Laterality
  • Humans
  • Magnetic Resonance Imaging
  • Middle Aged
  • Neuropsychological Tests
  • Psychomotor Performance
  • Twins, Monozygotic

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