Crystal structure of mammalian purple acid phosphatase

L W Guddat, A S McAlpine, D Hume, S Hamilton, J de Jersey, J L Martin

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Mammalian purple acid phosphatases are highly conserved binuclear metal-containing enzymes produced by osteoclasts, the cells that resorb bone. The enzyme is a target for drug design because there is strong evidence that it is involved in bone resorption.
Original languageEnglish
Pages (from-to)757-67
Number of pages11
Issue number7
Publication statusPublished - 15 Jul 1999

Keywords / Materials (for Non-textual outputs)

  • Acid Phosphatase
  • Amino Acid Sequence
  • Animals
  • Binding Sites
  • Catalytic Domain
  • Crystallography, X-Ray
  • Glycoproteins
  • Humans
  • Models, Molecular
  • Molecular Sequence Data
  • Protein Conformation
  • Sequence Homology, Amino Acid
  • Swine


Dive into the research topics of 'Crystal structure of mammalian purple acid phosphatase'. Together they form a unique fingerprint.

Cite this