Crystal structure of p19 - a universal suppressor of RNA silencing

DC Baulcombe*, A Molnar

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

RNA silencing in plants has an antiviral role and, consequently, plant viruses encode counter-defensive suppressor proteins that block this process. The recently reported crystal structure of two Tombusvirus suppressor proteins reveals a novel RNA-binding structure and illustrates precisely how the silencing mechanism is blocked. These suppressor protein structures, combined with molecular analyses of their effects in animal and plant cells, are informative about RNA silencing mechanisms. They also suggest various ways that Tombusvirus suppressors can be used to investigate RNA silencing in plants and animals.

Original languageEnglish
Pages (from-to)279-281
Number of pages3
JournalTrends in biochemical sciences
Volume29
Issue number6
Publication statusPublished - Jun 2004

Keywords / Materials (for Non-textual outputs)

  • SHORT INTERFERING RNA
  • VIRAL SUPPRESSOR
  • PROTEIN
  • PLANTS
  • RECOGNITION
  • MECHANISM
  • VIRUSES
  • COMPLEX
  • SIRNA

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