Projects per year
Abstract
Regulatory mechanisms controlling the pool size of spleen dendritic cells (DC) remain incompletely understood. DCs are continuously replenished from hematopoietic stem cells, and FLT3-mediated signals cell-intrinsically regulate homeostatic expansion of spleen DCs. Here we show that combining FLT3 and CSF1R-deficiencies results in specific and complete abrogation of spleen DCs in vivo. Spatiotemporally controlled CSF1R depletion reveals a cell-extrinsic and non-hematopoietic mechanism for DC pool size regulation. Lack of CSF1R-mediated signals impedes the differentiation of spleen macrophages of embryonic origin, and the resulted macrophage depletion during development or in adult mice results in loss of DCs. Moreover, embryo-derived macrophages are important for the physiologic regeneration of DC after activation-induced depletion in situ. In summary, we show that the differentiation of DC and their regeneration relies on ontogenetically distinct spleen macrophages, thereby providing a novel regulatory principle that may also be important for the differentiation of other hematopoietic cell types.
Original language | English |
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Article number | 5279 |
Number of pages | 12 |
Journal | Nature Communications |
Volume | 9 |
DOIs | |
Publication status | Published - 11 Dec 2018 |
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Dive into the research topics of 'CSF1R regulates the dendritic cell pool size in adult mice via embryo-derived tissue-resident macrophages'. Together they form a unique fingerprint.Projects
- 3 Finished
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MRC Centre for Reproductive Health at the University of Edinburgh
Pollard, J.
12/09/16 → 11/09/22
Project: Research
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Integrated Multi-Dimensional Molecular Organ Imaging
Wiegand, R. & Pollard, J.
1/02/13 → 31/01/16
Project: Research