CT-measured bone attenuation in patients with chronic obstructive pulmonary disease: relation to clinical features and outcomes

Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE) Study Investigators; Elisabeth A P M Romme; John T Murchison; Lisa D Edwards; Edwin van Beek; David M Murchison; Erica P A Rutten; Frank W J M Smeenk; Michelle C Williams; Emiel F M Wouters; William MacNee

doi:10.1002/jbmr.1873

CT-measured bone attenuation in patients with chronic obstructive pulmonary disease: relation to clinical features and outcomes

Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE) Study Investigators
, Elisabeth A P M Romme
, John T Murchison
, Lisa D Edwards
, Edwin van Beek
, David M Murchison
, Erica P A Rutten
, Frank W J M Smeenk
, Michelle C Williams
, Emiel F M Wouters
, William MacNee

Research output: Contribution to journal › Article › peer-review

Abstract

Osteoporosis is highly prevalent in chronic obstructive pulmonary disease (COPD) patients and has been related to several clinical features. However, most studies have been in relatively small COPD cohorts. Therefore, the objectives of this study were to compare bone attenuation measured on low-dose chest computed tomography (CT) between COPD subjects and smoker and nonsmoker controls, and to relate bone attenuation to clinical parameters, inflammatory biomarkers, and outcomes in a large, well-characterized COPD cohort. We studied 1634 COPD subjects, 259 smoker controls, and 186 nonsmoker controls who participated in a large longitudinal study (ECLIPSE). We measured bone attenuation, extent of emphysema, and coronary artery calcification (Agatston score) on baseline CT scans, and clinical parameters, inflammatory biomarkers, and outcomes. Bone attenuation was lower in COPD subjects compared with smoker and nonsmoker controls (164.9 ± 49.5 Hounsfield units [HU] versus 183.8 ± 46.1 HU versus 212.1 ± 54.4 HU, p

Original language	English
Pages (from-to)	1369-77
Number of pages	9
Journal	Journal of Bone and Mineral Research
Volume	28
Issue number	6
DOIs	https://doi.org/10.1002/jbmr.1873
Publication status	Published - Jun 2013

Keywords / Materials (for Non-textual outputs)

Adult
Age Factors
Aged
Bone and Bones
Cohort Studies
Coronary Artery Disease
Coronary Vessels
Female
Humans
Male
Middle Aged
Osteoporosis
Pulmonary Disease, Chronic Obstructive
Sex Factors
Smoking
Tomography, X-Ray Computed
Vascular Calcification

Access to Document

10.1002/jbmr.1873

http://onlinelibrary.wiley.com/doi/10.1002/jbmr.1873/abstract

PhD STUDENT - JOANNE SIMPSON - Supervisor MOHINI GRAY
Iredale, J. (Principal Investigator)
MRC
1/09/12 → 31/08/16
Project: Research

Cite this

Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE) Study Investigators, Romme, E. A. P. M., Murchison, J. T., Edwards, L. D., van Beek, E., Murchison, D. M., Rutten, E. P. A., Smeenk, F. W. J. M., Williams, M. C., Wouters, E. F. M., & MacNee, W. (2013). CT-measured bone attenuation in patients with chronic obstructive pulmonary disease: relation to clinical features and outcomes. Journal of Bone and Mineral Research, 28(6), 1369-77. https://doi.org/10.1002/jbmr.1873

@article{850ece67ce5c4fb29048d32dfead3006,

title = "CT-measured bone attenuation in patients with chronic obstructive pulmonary disease: relation to clinical features and outcomes",

abstract = "Osteoporosis is highly prevalent in chronic obstructive pulmonary disease (COPD) patients and has been related to several clinical features. However, most studies have been in relatively small COPD cohorts. Therefore, the objectives of this study were to compare bone attenuation measured on low-dose chest computed tomography (CT) between COPD subjects and smoker and nonsmoker controls, and to relate bone attenuation to clinical parameters, inflammatory biomarkers, and outcomes in a large, well-characterized COPD cohort. We studied 1634 COPD subjects, 259 smoker controls, and 186 nonsmoker controls who participated in a large longitudinal study (ECLIPSE). We measured bone attenuation, extent of emphysema, and coronary artery calcification (Agatston score) on baseline CT scans, and clinical parameters, inflammatory biomarkers, and outcomes. Bone attenuation was lower in COPD subjects compared with smoker and nonsmoker controls (164.9 ± 49.5 Hounsfield units [HU] versus 183.8 ± 46.1 HU versus 212.1 ± 54.4 HU, p ",

keywords = "Adult, Age Factors, Aged, Bone and Bones, Cohort Studies, Coronary Artery Disease, Coronary Vessels, Female, Humans, Male, Middle Aged, Osteoporosis, Pulmonary Disease, Chronic Obstructive, Sex Factors, Smoking, Tomography, X-Ray Computed, Vascular Calcification",

author = "\{Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE) Study Investigators\} and Romme, \{Elisabeth A P M\} and Murchison, \{John T\} and Edwards, \{Lisa D\} and \{van Beek\}, Edwin and Murchison, \{David M\} and Rutten, \{Erica P A\} and Smeenk, \{Frank W J M\} and Williams, \{Michelle C\} and Wouters, \{Emiel F M\} and William MacNee",

note = "Copyright {\textcopyright} 2013 American Society for Bone and Mineral Research.",

year = "2013",

month = jun,

doi = "10.1002/jbmr.1873",

language = "English",

volume = "28",

pages = "1369--77",

journal = "Journal of Bone and Mineral Research",

issn = "0884-0431",

publisher = "Oxford University Press",

number = "6",

}

Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE) Study Investigators, Romme, EAPM, Murchison, JT, Edwards, LD, van Beek, E, Murchison, DM, Rutten, EPA, Smeenk, FWJM, Williams, MC, Wouters, EFM & MacNee, W 2013, 'CT-measured bone attenuation in patients with chronic obstructive pulmonary disease: relation to clinical features and outcomes', Journal of Bone and Mineral Research, vol. 28, no. 6, pp. 1369-77. https://doi.org/10.1002/jbmr.1873

CT-measured bone attenuation in patients with chronic obstructive pulmonary disease: relation to clinical features and outcomes. / Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE) Study Investigators; Romme, Elisabeth A P M; Murchison, John T et al.
In: Journal of Bone and Mineral Research, Vol. 28, No. 6, 06.2013, p. 1369-77.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - CT-measured bone attenuation in patients with chronic obstructive pulmonary disease

T2 - relation to clinical features and outcomes

AU - Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE) Study Investigators

AU - Romme, Elisabeth A P M

AU - Murchison, John T

AU - Edwards, Lisa D

AU - van Beek, Edwin

AU - Murchison, David M

AU - Rutten, Erica P A

AU - Smeenk, Frank W J M

AU - Williams, Michelle C

AU - Wouters, Emiel F M

AU - MacNee, William

PY - 2013/6

Y1 - 2013/6

N2 - Osteoporosis is highly prevalent in chronic obstructive pulmonary disease (COPD) patients and has been related to several clinical features. However, most studies have been in relatively small COPD cohorts. Therefore, the objectives of this study were to compare bone attenuation measured on low-dose chest computed tomography (CT) between COPD subjects and smoker and nonsmoker controls, and to relate bone attenuation to clinical parameters, inflammatory biomarkers, and outcomes in a large, well-characterized COPD cohort. We studied 1634 COPD subjects, 259 smoker controls, and 186 nonsmoker controls who participated in a large longitudinal study (ECLIPSE). We measured bone attenuation, extent of emphysema, and coronary artery calcification (Agatston score) on baseline CT scans, and clinical parameters, inflammatory biomarkers, and outcomes. Bone attenuation was lower in COPD subjects compared with smoker and nonsmoker controls (164.9 ± 49.5 Hounsfield units [HU] versus 183.8 ± 46.1 HU versus 212.1 ± 54.4 HU, p

AB - Osteoporosis is highly prevalent in chronic obstructive pulmonary disease (COPD) patients and has been related to several clinical features. However, most studies have been in relatively small COPD cohorts. Therefore, the objectives of this study were to compare bone attenuation measured on low-dose chest computed tomography (CT) between COPD subjects and smoker and nonsmoker controls, and to relate bone attenuation to clinical parameters, inflammatory biomarkers, and outcomes in a large, well-characterized COPD cohort. We studied 1634 COPD subjects, 259 smoker controls, and 186 nonsmoker controls who participated in a large longitudinal study (ECLIPSE). We measured bone attenuation, extent of emphysema, and coronary artery calcification (Agatston score) on baseline CT scans, and clinical parameters, inflammatory biomarkers, and outcomes. Bone attenuation was lower in COPD subjects compared with smoker and nonsmoker controls (164.9 ± 49.5 Hounsfield units [HU] versus 183.8 ± 46.1 HU versus 212.1 ± 54.4 HU, p

KW - Adult

KW - Age Factors

KW - Aged

KW - Bone and Bones

KW - Cohort Studies

KW - Coronary Artery Disease

KW - Coronary Vessels

KW - Female

KW - Humans

KW - Male

KW - Middle Aged

KW - Osteoporosis

KW - Pulmonary Disease, Chronic Obstructive

KW - Sex Factors

KW - Smoking

KW - Tomography, X-Ray Computed

KW - Vascular Calcification

U2 - 10.1002/jbmr.1873

DO - 10.1002/jbmr.1873

M3 - Article

C2 - 23361992

SN - 0884-0431

VL - 28

SP - 1369

EP - 1377

JO - Journal of Bone and Mineral Research

JF - Journal of Bone and Mineral Research

IS - 6

ER -

Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE) Study Investigators, Romme EAPM, Murchison JT, Edwards LD, van Beek E, Murchison DM et al. CT-measured bone attenuation in patients with chronic obstructive pulmonary disease: relation to clinical features and outcomes. Journal of Bone and Mineral Research. 2013 Jun;28(6):1369-77. doi: 10.1002/jbmr.1873

CT-measured bone attenuation in patients with chronic obstructive pulmonary disease: relation to clinical features and outcomes

Abstract

Keywords / Materials (for Non-textual outputs)

Access to Document

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Projects

PhD STUDENT - JOANNE SIMPSON - Supervisor MOHINI GRAY

Cite this