Cu(I)-catalyzed reductive aldol cyclizations: Diastereo- and enantioselective synthesis of beta-hydroxylactones

H W Lam, P M Joensuu, Hon Lam

Research output: Contribution to journalArticlepeer-review

Abstract

Copper bisphosphine complexes catalyze the intramolecular reductive aldol reaction of alpha,beta-unsaturated esters with ketones, affording five-and six-membered beta-hydroxylactones in high stereoselectivities. Utilization of chiral nonracemic bisphosphines render the cyclizations enantioselective.

Original languageEnglish
Pages (from-to)4225-4228
Number of pages4
JournalOrganic letters
Volume7
Issue number19
DOIs
Publication statusPublished - 15 Sept 2005

Keywords / Materials (for Non-textual outputs)

  • ALPHA,BETA-UNSATURATED CARBONYL-COMPOUNDS
  • CONJUGATE REDUCTION
  • ASYMMETRIC HYDROSILYLATION
  • STRYKERS REAGENT
  • KETONES
  • ESTERS
  • HYDROGENATION
  • GENERATION
  • ALDEHYDES
  • HYDRIDE

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