Abstract
Copper bisphosphine complexes catalyze the intramolecular reductive aldol reaction of alpha,beta-unsaturated esters with ketones, affording five-and six-membered beta-hydroxylactones in high stereoselectivities. Utilization of chiral nonracemic bisphosphines render the cyclizations enantioselective.
Original language | English |
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Pages (from-to) | 4225-4228 |
Number of pages | 4 |
Journal | Organic letters |
Volume | 7 |
Issue number | 19 |
DOIs | |
Publication status | Published - 15 Sept 2005 |
Keywords / Materials (for Non-textual outputs)
- ALPHA,BETA-UNSATURATED CARBONYL-COMPOUNDS
- CONJUGATE REDUCTION
- ASYMMETRIC HYDROSILYLATION
- STRYKERS REAGENT
- KETONES
- ESTERS
- HYDROGENATION
- GENERATION
- ALDEHYDES
- HYDRIDE