Culture of human ovarian follicles from primordial stages to maturity

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)peer-review

Abstract / Description of output

Cryopreservation of ovarian tissue is now widely used to preserve the fertility of girls and young women at high risk of sterility. Fragments of ovarian cortex can be autografted to an orthotopic or heterotopic site to restore fertility. For girls and women with blood-borne leukaemias or cancers with a high risk of ovarian metastasis, ovarian autografting risks re-introduction of the cancer. For these girls and women, fertility restoration could only be safely achieved in the laboratory by the complete in vitro growth (IVG) and maturation (IVM) of cryopreserved primordial follicles to fertile metaphase II (MII) oocytes.

The technology required to culture human follicles is extremely challenging, but significant advances have been made. This chapter details the progress that has been made in developing human in vitro growth systems.
Original languageEnglish
Title of host publicationFemale and Male Fertility Preservation
EditorsMichael Grynberg, Pasquale Patrizio
PublisherSpringerLink
Pages375-385
Number of pages11
ISBN (Electronic)978-3-030-47767-7
ISBN (Print)978-3-030-47766-0
DOIs
Publication statusPublished - 1 Jan 2022

Keywords / Materials (for Non-textual outputs)

  • fertility
  • follicle culture
  • ovary
  • oocyte
  • IVG
  • IVGM
  • IVF

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