Culture of human ovarian follicles from primordial stages to maturity

Evelyn E Telfer

doi:10.1007/978-3-030-47767-7_30

Culture of human ovarian follicles from primordial stages to maturity

Evelyn E Telfer

School of Biological Sciences

Research output: Chapter in Book/Report/Conference proceeding › Chapter (peer-reviewed) › peer-review

Abstract

Cryopreservation of ovarian tissue is now widely used to preserve the fertility of girls and young women at high risk of sterility. Fragments of ovarian cortex can be autografted to an orthotopic or heterotopic site to restore fertility. For girls and women with blood-borne leukaemias or cancers with a high risk of ovarian metastasis, ovarian autografting risks re-introduction of the cancer. For these girls and women, fertility restoration could only be safely achieved in the laboratory by the complete in vitro growth (IVG) and maturation (IVM) of cryopreserved primordial follicles to fertile metaphase II (MII) oocytes.

The technology required to culture human follicles is extremely challenging, but significant advances have been made. This chapter details the progress that has been made in developing human in vitro growth systems.

Original language	English
Title of host publication	Female and Male Fertility Preservation
Editors	Michael Grynberg, Pasquale Patrizio
Publisher	SpringerLink
Pages	375-385
Number of pages	11
ISBN (Electronic)	978-3-030-47767-7
ISBN (Print)	978-3-030-47766-0
DOIs	https://doi.org/10.1007/978-3-030-47767-7_30
Publication status	Published - 1 Jan 2022

Keywords / Materials (for Non-textual outputs)

fertility
follicle culture
ovary
oocyte
IVG
IVGM
IVF

Access to Document

10.1007/978-3-030-47767-7_30

Cite this

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AB - Cryopreservation of ovarian tissue is now widely used to preserve the fertility of girls and young women at high risk of sterility. Fragments of ovarian cortex can be autografted to an orthotopic or heterotopic site to restore fertility. For girls and women with blood-borne leukaemias or cancers with a high risk of ovarian metastasis, ovarian autografting risks re-introduction of the cancer. For these girls and women, fertility restoration could only be safely achieved in the laboratory by the complete in vitro growth (IVG) and maturation (IVM) of cryopreserved primordial follicles to fertile metaphase II (MII) oocytes.The technology required to culture human follicles is extremely challenging, but significant advances have been made. This chapter details the progress that has been made in developing human in vitro growth systems.

KW - fertility

KW - follicle culture

KW - ovary

KW - oocyte

KW - IVG

KW - IVGM

KW - IVF

U2 - 10.1007/978-3-030-47767-7_30

DO - 10.1007/978-3-030-47767-7_30

M3 - Chapter (peer-reviewed)

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BT - Female and Male Fertility Preservation

A2 - Grynberg, Michael

A2 - Patrizio, Pasquale

PB - SpringerLink

ER -

Culture of human ovarian follicles from primordial stages to maturity

Abstract

Keywords / Materials (for Non-textual outputs)

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