Current views on the molecular mechanisms responsible for the development of hepatocellular carcinoma

P. N. Newsome; Y. Moussa; J. N. Plevris; P. C. Hayes

Current views on the molecular mechanisms responsible for the development of hepatocellular carcinoma

P. N. Newsome^*, Y. Moussa, J. N. Plevris, P. C. Hayes

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

Abstract

Hepatocellular carcinoma is one of the commonest malignant tumours in the world and displays striking geographical variation which largely reflects the distribution of its major aetiologies: hepatitis B/C and aflatoxin ingestion. Whilst these agents are known to act synergistically with chronic liver damage/cirrhosis to establish neoplastic transformation, there is sufficient evidence to indicate that they have direct carcinogenic activity. In this review we examine the chemical and viral oncogenic mechanisms which interact to produce a malignancy which still confers a grave prognosis.

Original language	English
Pages (from-to)	251-259
Number of pages	9
Journal	Medical Biochemistry
Volume	1
Issue number	4
Publication status	Published - 2001

Keywords

Aflatoxins
Hepatitis B virus
Hepatitis C virus
Hepatocellular carcinoma
Insulin-like growth factor
Nitric oxide
p53
Transforming growth factor α/β

Cite this

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title = "Current views on the molecular mechanisms responsible for the development of hepatocellular carcinoma",

abstract = "Hepatocellular carcinoma is one of the commonest malignant tumours in the world and displays striking geographical variation which largely reflects the distribution of its major aetiologies: hepatitis B/C and aflatoxin ingestion. Whilst these agents are known to act synergistically with chronic liver damage/cirrhosis to establish neoplastic transformation, there is sufficient evidence to indicate that they have direct carcinogenic activity. In this review we examine the chemical and viral oncogenic mechanisms which interact to produce a malignancy which still confers a grave prognosis.",

keywords = "Aflatoxins, Hepatitis B virus, Hepatitis C virus, Hepatocellular carcinoma, Insulin-like growth factor, Nitric oxide, p53, Transforming growth factor α/β",

author = "Newsome, {P. N.} and Y. Moussa and Plevris, {J. N.} and Hayes, {P. C.}",

year = "2001",

language = "English",

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pages = "251--259",

journal = "Medical Biochemistry",

issn = "1027-0256",

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T1 - Current views on the molecular mechanisms responsible for the development of hepatocellular carcinoma

AU - Newsome, P. N.

AU - Moussa, Y.

AU - Plevris, J. N.

AU - Hayes, P. C.

PY - 2001

Y1 - 2001

N2 - Hepatocellular carcinoma is one of the commonest malignant tumours in the world and displays striking geographical variation which largely reflects the distribution of its major aetiologies: hepatitis B/C and aflatoxin ingestion. Whilst these agents are known to act synergistically with chronic liver damage/cirrhosis to establish neoplastic transformation, there is sufficient evidence to indicate that they have direct carcinogenic activity. In this review we examine the chemical and viral oncogenic mechanisms which interact to produce a malignancy which still confers a grave prognosis.

AB - Hepatocellular carcinoma is one of the commonest malignant tumours in the world and displays striking geographical variation which largely reflects the distribution of its major aetiologies: hepatitis B/C and aflatoxin ingestion. Whilst these agents are known to act synergistically with chronic liver damage/cirrhosis to establish neoplastic transformation, there is sufficient evidence to indicate that they have direct carcinogenic activity. In this review we examine the chemical and viral oncogenic mechanisms which interact to produce a malignancy which still confers a grave prognosis.

KW - Aflatoxins

KW - Hepatitis B virus

KW - Hepatitis C virus

KW - Hepatocellular carcinoma

KW - Insulin-like growth factor

KW - Nitric oxide

KW - p53

KW - Transforming growth factor α/β

UR - http://www.scopus.com/inward/record.url?scp=0034795856&partnerID=8YFLogxK

M3 - Review article

AN - SCOPUS:0034795856

VL - 1

SP - 251

EP - 259

JO - Medical Biochemistry

JF - Medical Biochemistry

SN - 1027-0256

IS - 4

ER -

Current views on the molecular mechanisms responsible for the development of hepatocellular carcinoma

Abstract

Keywords

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