Customizing cell signaling using engineered genetic logic circuits

B. Wang, M. Buck

Research output: Contribution to journalArticlepeer-review


Cells live in an ever-changing environment and continuously sense, process and react to environmental signals using their inherent signaling and gene regulatory networks. Recently, there have been great advances on rewiring the native cell signaling and gene networks to program cells to sense multiple noncognate signals and integrate them in a logical manner before initiating a desired response. Here, we summarize the current state-of-the-art of engineering synthetic genetic logic circuits to customize cellular signaling behaviors, and discuss their promising applications in biocomputing, environmental, biotechnological and biomedical areas as well as the remaining challenges in this growing field.
Original languageEnglish
Pages (from-to)376-384
Number of pages9
JournalTrends in Microbiology
Issue number8
Publication statusPublished - Aug 2012


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