Abstract / Description of output
To assess the influence of dendritic cell (DC) production of polarizing cytokines on Th2 and Th1 development we transferred Ag-pulsed DC generated from wild-type, IL-4(-/-), or IL-12(-/-) mice into wild-type, IL-4(-/-), or IL-12(-/-) recipients. We found that DC IL-4 was not necessary for Th2 induction and that, surprisingly, DC IL-12 was not an absolute requirement for Th1 development. However, DC IL-12 production facilitated optimal Th1 response development. Critically, recipient ability to produce IL-4 or IL-12 was essential for either Th2 or Th1 development. These data help delineate the source and importance of IL-4 and IL-12 in the process of induction of polarized T cell responses by DC.
| Original language | English |
|---|---|
| Pages (from-to) | 3127-30 |
| Number of pages | 4 |
| Journal | The Journal of Immunology |
| Volume | 168 |
| Issue number | 7 |
| Publication status | Published - 2002 |
Keywords / Materials (for Non-textual outputs)
- Adoptive Transfer
- Animals
- Antigens, Bacterial
- Antigens, Helminth
- Cell Differentiation
- Dendritic Cells
- Interleukin-12
- Interleukin-4
- Lymphocyte Activation
- Mice
- Mice, Inbred C57BL
- Mice, Knockout
- Th1 Cells
- Th2 Cells