Cutting edge: polarized Th cell response induction by transferred antigen-pulsed dendritic cells is dependent on IL-4 or IL-12 production by recipient cells

Andrew S MacDonald, Edward J Pearce

Research output: Contribution to journalArticlepeer-review

Abstract

To assess the influence of dendritic cell (DC) production of polarizing cytokines on Th2 and Th1 development we transferred Ag-pulsed DC generated from wild-type, IL-4(-/-), or IL-12(-/-) mice into wild-type, IL-4(-/-), or IL-12(-/-) recipients. We found that DC IL-4 was not necessary for Th2 induction and that, surprisingly, DC IL-12 was not an absolute requirement for Th1 development. However, DC IL-12 production facilitated optimal Th1 response development. Critically, recipient ability to produce IL-4 or IL-12 was essential for either Th2 or Th1 development. These data help delineate the source and importance of IL-4 and IL-12 in the process of induction of polarized T cell responses by DC.
Original languageEnglish
Pages (from-to)3127-30
Number of pages4
JournalJournal of Immunology
Volume168
Issue number7
Publication statusPublished - 2002

Keywords

  • Adoptive Transfer
  • Animals
  • Antigens, Bacterial
  • Antigens, Helminth
  • Cell Differentiation
  • Dendritic Cells
  • Interleukin-12
  • Interleukin-4
  • Lymphocyte Activation
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Th1 Cells
  • Th2 Cells

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