Cyclic GMP protects human macrophages against peroxynitrite-induced apoptosis

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Nitric oxide (NO) can be both pro- and anti-apoptotic in various cell types, including macrophages. This apparent paradox may result from the actions of NO-related species generated in the microenvironment of the cell, for example the formation of peroxynitrite (ONOO-). In this study we have examined the ability of NO and ONOO- to evoke apoptosis in human monocyte-derived macrophages (MDMvarphi), and investigated whether preconditioning by cyclic guanosine monophosphate (cGMP) is able to limit apoptosis in this cell type.
Original languageEnglish
Article number14
Number of pages10
JournalJournal of inflammation
Publication statusPublished - May 2009


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