Cyclic GMP protects human macrophages against peroxynitrite-induced apoptosis

Catherine A Shaw; David J Webb; Adriano G Rossi; Ian L Megson

doi:10.1186/1476-9255-6-14

Cyclic GMP protects human macrophages against peroxynitrite-induced apoptosis

Catherine A Shaw, David J Webb, Adriano G Rossi, Ian L Megson

Research output: Contribution to journal › Article › peer-review

Abstract / Description of output

Nitric oxide (NO) can be both pro- and anti-apoptotic in various cell types, including macrophages. This apparent paradox may result from the actions of NO-related species generated in the microenvironment of the cell, for example the formation of peroxynitrite (ONOO-). In this study we have examined the ability of NO and ONOO- to evoke apoptosis in human monocyte-derived macrophages (MDMvarphi), and investigated whether preconditioning by cyclic guanosine monophosphate (cGMP) is able to limit apoptosis in this cell type.

Original language	English
Article number	14
Number of pages	10
Journal	Journal of inflammation
Volume	6
DOIs	https://doi.org/10.1186/1476-9255-6-14
Publication status	Published - May 2009

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10.1186/1476-9255-6-14

Cyclic GMP protects human macrophages against peroxynitrite-induced apoptosis
http://www.journal-inflammation.com/content/6/1/14
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http://www.journal-inflammation.com/content/6/1/14

Induction of neutrophil apoptosis and treatment of severe lung inflammation
Rossi, A.
MRC
1/09/07 → 29/02/12
Project: Research

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title = "Cyclic GMP protects human macrophages against peroxynitrite-induced apoptosis",

abstract = "Nitric oxide (NO) can be both pro- and anti-apoptotic in various cell types, including macrophages. This apparent paradox may result from the actions of NO-related species generated in the microenvironment of the cell, for example the formation of peroxynitrite (ONOO-). In this study we have examined the ability of NO and ONOO- to evoke apoptosis in human monocyte-derived macrophages (MDMvarphi), and investigated whether preconditioning by cyclic guanosine monophosphate (cGMP) is able to limit apoptosis in this cell type.",

author = "Shaw, {Catherine A} and Webb, {David J} and Rossi, {Adriano G} and Megson, {Ian L}",

year = "2009",

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language = "English",

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AU - Webb, David J

AU - Rossi, Adriano G

AU - Megson, Ian L

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AB - Nitric oxide (NO) can be both pro- and anti-apoptotic in various cell types, including macrophages. This apparent paradox may result from the actions of NO-related species generated in the microenvironment of the cell, for example the formation of peroxynitrite (ONOO-). In this study we have examined the ability of NO and ONOO- to evoke apoptosis in human monocyte-derived macrophages (MDMvarphi), and investigated whether preconditioning by cyclic guanosine monophosphate (cGMP) is able to limit apoptosis in this cell type.

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DO - 10.1186/1476-9255-6-14

M3 - Article

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SN - 1476-9255

VL - 6

JO - Journal of inflammation

JF - Journal of inflammation

M1 - 14

ER -

Cyclic GMP protects human macrophages against peroxynitrite-induced apoptosis

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Induction of neutrophil apoptosis and treatment of severe lung inflammation

Cite this