Cyclin D1, Id1 and EMT in breast cancer

Nicholas P Tobin, Andrew H Sims, Katja L Lundgren, Sophie Lehn, Göran Landberg

Research output: Contribution to journalArticlepeer-review

Abstract

Cyclin D1 is a well-characterised cell cycle regulator with established oncogenic capabilities. Despite these properties, studies report contrasting links to tumour aggressiveness. It has previously been shown that silencing cyclin D1 increases the migratory capacity of MDA-MB-231 breast cancer cells with concomitant increase in 'inhibitor of differentiation 1' (ID1) gene expression. Id1 is known to be associated with more invasive features of cancer and with the epithelial-mesenchymal transition (EMT). Here, we sought to determine if the increase in cell motility following cyclin D1 silencing was mediated by Id1 and enhanced EMT-features. To further substantiate these findings we aimed to delineate the link between CCND1, ID1 and EMT, as well as clinical properties in primary breast cancer.
Original languageEnglish
Pages (from-to)1-14
Number of pages14
JournalBMC Cancer
Volume11
Issue number417
DOIs
Publication statusPublished - 28 Sep 2011

Keywords

  • Cyclin D1
  • Id1
  • EMT
  • breast cancer
  • migration
  • recurrence-free survival
  • claudin-low

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