Cytogenetic evidence for the origin of neoplastic cells in CD5-positive marginal zone B-cell lymphoma

Paul Batstone, Linda Forsyth, John R Goodlad

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

We describe an 87-year-old female patient presenting with a breast lump and axillary lymphadenopathy. Histological examination revealed the lump to be a CD5-positive extranodal marginal zone B-cell lymphoma (MZBCL) of mucosa-associated lymphoid tissue. Subsequent staging revealed disseminated disease including the head and neck region. Only 2 cases of CD5-positive MZBCL have undergone any form of cytogenetic analysis, and we report the first standard karyotype of such a case. This revealed partial trisomy 3,7q deletion and an additional marker chromosome. Notably, cells lacked the t(11;14) found at high frequency in mantle cell lymphoma and trisomy 12 found in B small lymphocytic lymphoma (B-SLL). These results, combined with the clinical, histological, and immunophenotypic picture, suggest a marginal zone origin for the neoplastic lymphocytes, rather than a relationship with mantle cell or small lymphocytic lymphoma.

Original languageEnglish
Pages (from-to)1065-7
Number of pages3
JournalHuman pathology
Volume34
Issue number10
Publication statusPublished - Oct 2003

Keywords / Materials (for Non-textual outputs)

  • Aged
  • Aged, 80 and over
  • Antigens, CD5
  • Biopsy, Fine-Needle
  • Chromosome Aberrations
  • Female
  • Head and Neck Neoplasms
  • Humans
  • Lymph Nodes
  • Lymphoma, B-Cell, Marginal Zone
  • Palliative Care
  • Spectral Karyotyping

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