Projects per year
Abstract
Recently, we found that Holstein cattle (Bos taurus taurus) displayed higher skin test prevalence and disease severity compared to zebu (Bos taurus indicus) herd-mates kept under identical husbandry conditions in Ethiopia. To determine whether these susceptibility differences were patent at the level of the innate immune system, we infected monocytes from naive Holstein or Sahiwal zebu cattle with either live virulent Mycobacterium tuberculosis or Mycobacterium bovis. The cytokine profile following infection was compared between the two breeds by measuring IL-1alpha, IL-6, IL-10, IL-12 and TNF-alpha as well as nitric oxide in culture supernatants. Our results suggested subtle differences in the cytokine profile because only infection-induced IL-6 production was significantly increased in monocytes from the more susceptible Holstein cattle.
| Original language | English |
|---|---|
| Pages (from-to) | 651-655 |
| Journal | Tropical Animal Health and Production |
| Volume | 44 |
| Issue number | 3 |
| Early online date | 16 Aug 2011 |
| DOIs | |
| Publication status | Published - 2012 |
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Dive into the research topics of 'Cytokine responses of Holstein and Sahiwal zebu derived monocytes after mycobacterial infection'. Together they form a unique fingerprint.Projects
- 2 Finished
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Innate immunity and endemic diseases in livestock species
Collie, D. (Principal Investigator), Beard, P. (Co-investigator), Bishop, S. (Co-investigator), Bronsvoort, M. (Co-investigator), Burt, D. (Co-investigator), Fitzgerald, R. (Co-investigator), Freeman, T. (Co-investigator), Gally, D. (Co-investigator), Gill, A. (Co-investigator), Glass, E. (Co-investigator), Hocking, P. (Co-investigator), Hope, J. (Co-investigator), Hume, D. (Co-investigator), Kaiser, P. (Co-investigator), Mabbott, N. (Co-investigator), McLachlan, G. (Co-investigator), Morrison, L. (Co-investigator), Stevens, J. (Co-investigator), Stevens, M. (Co-investigator) & Watson, M. (Co-investigator)
1/04/12 → 31/03/17
Project: Research
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An Intergrated approach for the development of sustainable methods to control tropical theileriosis
Glass, E. (Principal Investigator)
1/05/08 → 30/11/10
Project: Research