Cytological and microbiological characteristics of middle ear effusions in brachycephalic dogs.

Elspeth Milne, Tim Nuttall, Katia Marioni-Henry, Chiara Piccinelli, Tobias Schwarz, Ali Anvari Azar, Jennifer Harris, Juliet Duncan, Michael Cheeseman

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Background: Middle ear effusion is common in brachycephalic dogs with similarities to otitis media with effusion in children. Association with cranial and Eustachian tube morphology and bacterial infection is suspected in both species.
Hypothesis/objectives: To determine cytological and bacteriological features of middle ear effusions in dogs, provide information on histological features and further assess the dog as a model of the human disease.
Animals: Sixteen live dogs, three post mortem cases of middle ear effusion, and two post mortem controls.
Methods: Prospective; clinical investigation using CT, MRI, video-otoscopy, myringotomy; cytological assessment of 30 and bacteriology of 28 effusions; histology and immunohistochemistry (CD3 for T-lymphocytes, Pax5 for B-lymphocytes and MAC387 for macrophages) of 10 middle ear sections.
Original languageEnglish
Pages (from-to)1454–1463
Number of pages9
JournalJournal of Veterinary Internal Medicine
Early online date14 May 2020
Publication statusPublished - 24 Jul 2020

Keywords / Materials (for Non-textual outputs)

  • Canine
  • Cavalier King Charles spaniel
  • Immunohistochemistry
  • Middle ear
  • Otitis Media With Effusion


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