Cytomegalovirus recruitment of cellular kinases to dissolve the nuclear lamina

W Muranyi, J Haas, M Wagner, G Krohne, U H Koszinowski

Research output: Contribution to journalArticlepeer-review

Abstract

The passage of large-sized herpesviral capsids through the nuclear lamina and the inner nuclear membrane to leave the nucleus requires a dissolution of the nuclear lamina. Here, we report on the functions of M50/p35, a beta-herpesviral protein of murine cytomegalovirus. M50/p35 inserts into the inner nuclear membrane and is aggregated by a second viral protein, M53/p38, to form the capsid docking site. M50/p35 recruits the cellular protein kinase C for phosphorylation and dissolution of the nuclear lamina, suggesting that herpesviruses target a critical element of nuclear architecture.

Original languageEnglish
Pages (from-to)854-857
Number of pages5
JournalScience
Volume297
Issue number5582
Publication statusPublished - 2 Aug 2002

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