Cytotoxic T cells in immunity to Theileria parva in cattle

Ivan Morrison, Bruno Goddeeris

Research output: Contribution to journalLiterature reviewpeer-review

Abstract

Theileria are tick-borne protozoan parasites which in their mammalian hosts successively utilise leukocytes and erythrocytes for completion of their life cycle. The parasites are found predominantly in ruminants. In domestic cattle, there are two species, namely T. annulata and T. parva, which cause economically important diseases. T. parva occurs throughout a large part of East and Central Africa where it causes an acute, usually fatal disease known as East Coast fever (ECF) (W.I. Morrison et al. 1986; Irvin and Morrison 1987). Control of the disease relies largely on regular application of acaricides to prevent tick infestation. This practice is costly, time consuming and can lead to selection of acaricide-resistant ticks. Thus an effective method of imunising against the disease would have a major impact on cattle production in ECF-endemic areas. To this end, studies have been undertaken to define the host immune responses involved in immunity against T. parva with the aim of identifying protentially protective antigens. These studies have yielded evidence that major histocompatibility complex (MHC) restricted cytotoxic T cells are important in mediating immunity.
Original languageEnglish
Pages (from-to)79-93
Number of pages15
JournalCurrent topics in microbiology and immunology
Volume155
DOIs
Publication statusPublished - 1990

Keywords

  • Animals
  • Apicomplexa/immunology
  • Cattle
  • Clone Cells
  • Host-Parasite Interactions
  • Immunity, Active/immunology
  • Major Histocompatibility Complex/genetics
  • Major Histocompatibility Complex/immunology
  • Phenotype
  • T-Lymphocytes, Cytotoxic/immunology
  • T-Lymphocytes, Helper-Inducer/immunology
  • Theileriasis/immunology
  • Theileriasis/parasitology

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