Cytotoxic T lymphocytes cleanse viral gene products from individually infected neurons and lymphocytes in mice persistently infected with lymphocytic choriomeningitis virus

A Tishon, M Eddleston, J C de la Torre, M B Oldstone

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Lymphocytes and/or monocytes/macrophages carry viral genetic information in most, if not all, persistent and latent viral infections, and serve as potential reservoirs for maintaining or reintroducing the infection. Similarly, neurons can be persistently infected by several DNA and RNA viruses whose continued presence can alter the physiologic function of these cells, leading to disorders in neurotransmitters and disease. Here, we document that adoptive transfer of virus-specific cytotoxic T lymphocytes clears virus and viral nucleic acid sequences, in vivo, from individually infected lymphocytes, macrophages, and neurons. By plaquing, infectious center, Northern blot, and in situ hybridization at the single cell level, virus was efficiently removed from these cells.

Original languageEnglish
Pages (from-to)463-7
Number of pages5
JournalVirology
Volume197
Issue number1
Publication statusPublished - Nov 1993

Keywords / Materials (for Non-textual outputs)

  • Animals
  • Antigens, CD4
  • Biomarkers
  • Cytotoxicity, Immunologic
  • Immunotherapy, Adoptive
  • Lymphocyte Depletion
  • Lymphocytes
  • Lymphocytic Choriomeningitis
  • Lymphocytic choriomeningitis virus
  • Male
  • Mice
  • Mice, Inbred BALB C
  • Neurons
  • T-Lymphocyte Subsets
  • T-Lymphocytes, Cytotoxic
  • Time Factors
  • Viral Plaque Assay

Fingerprint

Dive into the research topics of 'Cytotoxic T lymphocytes cleanse viral gene products from individually infected neurons and lymphocytes in mice persistently infected with lymphocytic choriomeningitis virus'. Together they form a unique fingerprint.

Cite this