Danish cohort of monozygotic inflammatory bowel disease twins: Clinical characteristics and inflammatory activity

Frederik Trier Moller*, Lina Knudsen, Marcus Harbord, Jack Satsangi, Hannah Gordon, Lene Christiansen, Kaare Christensen, Tine Jess, Vibeke Andersen

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

AIM: To describe the establishment of a Danish inflammatory bowel diseases (IBD) twin cohort with focus on concordance of treatment and inflammatory markers.

METHODS: We identified MZ twins, likely to be discordant or concordant for IBD, by merging information from the Danish Twin Register and the National Patient Register. The twins were asked to provide biological samples, questionnaires, and data access to patient files and public registries. Biological samples were collected via a mobile laboratory, which allowed for immediate centrifugation, fractionation, and storage of samples. The mean time from collection of samples to storage in the -80 degrees C mobile freezer was less than one hour. The diagnoses where validated using the Copenhagen diagnostic criteria.

RESULTS: We identified 159 MZ IBD twin pairs, in a total of 62 (39%) pairs both twins agreed to participate. Of the supposed 62 IBD pairs, the IBD diagnosis could be confirmed in 54 pairs. The cohort included 10 concordant pairs, whereof some were discordant for either treatment or surgery. The 10 concordant pairs, where both pairs suffered from IBD, included eight CD/CD pairs, one UC/UC pair and one UC/IBDU pair. The discordant pairs comprised 31 UC, 5 IBDU (IBD unclassified), and 8 CD discordant pairs. In the co-twins not affected by IBD, calprotectin was above 100 mu g/g in 2 participants, and above 50 mu g/g in a further 5 participants.

CONCLUSION: The presented IBD twin cohorts are an excellent resource for bioinformatics studies with proper adjustment for disease-associated exposures including medication and inflammatory activity in the co-twins.

Original languageEnglish
Pages (from-to)5050-5059
Number of pages10
JournalWorld Journal of Gastroenterology
Issue number21
Early online date7 Jun 2016
Publication statusE-pub ahead of print - 7 Jun 2016

Keywords / Materials (for Non-textual outputs)

  • Digestive system diseases
  • Inflammatory bowel diseases
  • Crohn's disease
  • Ulcerative colitis
  • Epidemiologic studies
  • Twins
  • Biobank


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